Endotoxin recognition and signal transduction by the TLR4/MD2-complex

ArticleinMicrobes and Infection 6(15):1361-7 · January 2005with28 Reads
Impact Factor: 2.86 · DOI: 10.1016/j.micinf.2004.08.015 · Source: PubMed
Abstract

Bacterial lipopolysaccharides are recognized in mammals by a receptor complex composed of CD14, Toll-like receptor (TLR)-4 and MD-2. Transduction of signaling is achieved following the recruitment of a combination of four Toll-interleukin-1 resistance (TIR)-domain-containing adapter molecules, which provide a structural platform enabling the recruitment and activation of downstream effectors essential for pathway-specific transcription factor activation and inflammatory gene expression.