Brain Activation Gradients in Ventrolateral Prefrontal Cortex Related to Persistence of ADHD in Adolescent Boys

Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029-6574, USA.
Journal of the American Academy of Child & Adolescent Psychiatry (Impact Factor: 7.26). 02/2005; 44(1):47-54. DOI: 10.1097/01.chi.0000145551.26813.f9
Source: PubMed


To explore the possible role that functional abnormalities of the prefrontal cortex and basal ganglia play in the persistence of attention-deficit/hyperactivity disorder (ADHD) in adolescents aged 15 to 19 years.
Ten male adolescents who were diagnosed with ADHD during childhood were grouped into those who continued to meet full diagnostic criteria for DSM-IV ADHD (persisters; n = 5) and those in whom symptoms had remitted sufficiently to warrant a diagnosis of ADHD in partial remission (remitters; n = 5). Persisters, remitters, and five carefully matched controls with no history of ADHD were scanned using functional magnetic resonance imaging while performing a go/no-go task.
Parallel linear trends were found in performance on the go/no-go task and activation of ventrolateral prefrontal cortex, such that persisters made the most commission errors (33%) and showed the greatest activation, remitters made fewer commission errors (24%) and had lower activity, and activation was lowest in controls who made the fewest errors (13%).
These preliminary results suggest that developmental changes in ADHD symptomatology are associated with functional changes in ventrolateral prefrontal cortex activity.

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Available from: Jin Fan, Aug 09, 2015
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    • "neuroimaging findings, individuals with ADHD have a wide array of neurocognitive deficits that likely contribute to their maladaptive behavior patterns (Frazier, Demaree, & Youngstrom, 2004; Willcutt, Doyle, Nigg, Faraone, & Pennington, 2005). Importantly, emerging neuroimaging (Schulz et al., 2005; Shaw et al., 2006; Suskauer et al., 2008) and neuropsychological (Halperin, Trampush, Miller, Marks, & Newcorn, 2008; Healey, Marks, & Halperin, 2011) data suggest that the diminution of ADHD symptoms is linked to the development of improved neural functioning . Thus, interventions that target neural growth and development may provide an avenue for more sustained benefits for ADHD. "
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