Pathologic quiz case: right knee pain in a 29-year-old man. Chondroblastoma with aneurysmal bone cyst formation.

Department of Pathology, Saint Barnabas Medical Center, Livingston, NJ 07039, USA.
Archives of pathology & laboratory medicine (Impact Factor: 2.84). 02/2005; 129(1):e16-8.
Source: PubMed
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    • "The location of a chondroblastoma in the patella was formerly considered highly unusual; however, ever since Ogden7) has emphasized the similarity between the patella and the epiphysis, it is thought that a chondroblastoma can also arise in the patella, which is formed from a cartilage focus. However, the chondroblastoma associated with an aneurysmal bone cyst has been rarely reported in a review of the literature4,8-10). Although the clinical presentation is highly variable, local pain, soft tissue swelling and tenderness are common presenting complaints. "
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    ABSTRACT: A 29-year-old woman complained of a 3-month history of left knee pain without trauma history. X-ray showed a well-defined osteolytic lesion with a sclerotic margin in the patella and magnetic resonance imaging showed T1-low and T2-high signal intensity with different fluid level. Our impression was an aneurysmal bone cyst. At surgery, the lesion was a blood-filled cystic cavity, surrounded by a gray or brownish tissue. Hemorrhagic soft tissues with recognizable bone fragments were observed. Curettage and autogenous bone graft was done. Microscopically, sheets of tumor cells were intermingled with some areas of eosinophilic chondroid matrix. The tumor cells showed oval-shaped nuclei with moderate eosinophilic cytoplasm. Several multinucleated giant cells and blood filled cystic cavities were observed. The final diagnosis was a chondroblastoma with a secondary aneurysmal bone cyst. At the post-operative 1.5-year follow-up, grafted bones were well incorporated radiographically and there were no recurrent evidence or any other abnormal symptoms.
    Full-text · Article · Mar 2014
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    ABSTRACT: Chondroblastoma is an uncommon osseous neoplasm that accounts for less than 1% of all bone tumours. It characteristically arises in the epiphysis or epimetaphyseal region of long bones and has been reported to affect people of all ages with slight male predilection. WHO has defined chondroblastoma as 'a benign, cartilage-producing neoplasm usually arising in the epiphyses of skeletally immature patients'. The authors document the cytological features on fine-needle aspiration cytology of a chondroblastoma which appeared as a lytic lesion in the upper end of the right fibula, an uncommon site, in an 18-year-old male patient. X-ray feature combined with fine-needle aspiration cytology favoured the diagnosis of chondroblastoma, which was further confirmed by histopathological examination.
    Full-text · Article · May 2014 · Case Reports