Benzimidazole derivatives as novel nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 1: Benzimidazole-5-sulfonamides

ArticleinBioorganic & Medicinal Chemistry Letters 15(3):799-803 · March 2005with14 Reads
Impact Factor: 2.42 · DOI: 10.1016/j.bmcl.2004.10.089 · Source: PubMed

    Abstract

    A new class of benzimidazole-5-sulfonamides has been identified as nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists. Initial structure-activity relationships are presented resulting in compounds 19 and 28 with submicromolar dual functional activity on human and rat receptors.