Ultraviolet B-Induced DNA Damage in Human Epidermis Is Modified by the Antioxidants Ascorbic Acid and D-α-Tocopherol

Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximillians-Universität, Frauenlobstr. 9-11, 80337 Munich, Germany.
Journal of Investigative Dermatology (Impact Factor: 7.22). 03/2005; 124(2):304-7. DOI: 10.1111/j.0022-202X.2004.23560.x
Source: PubMed


DNA damage caused by ultraviolet (UV) irradiation is considered the main etiologic factor contributing to the development of skin cancer. Systemic or topical application of antioxidants has been suggested as a protective measure against UV-induced skin damage. We investigated the effect of long-term oral administration of a combination of the antioxidants ascorbic acid (vitamin C) and D-alpha-tocopherol (vitamin E) in human volunteers on UVB-induced epidermal damage. The intake of vitamins C and E for a period of 3 mo significantly reduced the sunburn reaction to UVB irradiation. Detection of thymine dimers in the skin using a specific antibody revealed a significant increase of this type of DNA damage following UVB exposure. After 3 mo of antioxidant administration, significantly less thymine dimers were induced by the UVB challenge, suggesting that antioxidant treatment protected against DNA damage.

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Available from: Urs Kerkmann, Feb 05, 2015
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    • "Maintains SPF for at least 30 minutes of heavy sweating * Includes sunscreens labeled as " very water resistant " 269-DNJ August 8/7/08 2:26 PM Page 269 mation of thymine dimers when taken orally in combination (Fuchs & Kern, 1998; Placzek et al., 2005). However, consuming either one alone does not offer the same level of protection (Fuchs & Kern, 1998). "
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