Changes in body fat and weight after a breast cancer diagnosis: Influence of demographic, prognostic, and lifestyle factors

Yale University, New Haven, Connecticut, United States
Journal of Clinical Oncology (Impact Factor: 18.43). 03/2005; 23(4):774-82. DOI: 10.1200/JCO.2005.04.036
Source: PubMed


Obese women and women who gain weight after a breast cancer diagnosis are at a greater risk for breast cancer recurrence and death compared with lean women and women who do not gain weight after diagnosis. In this population-based study, we assessed weight and body fat changes from during the first year of diagnosis to during the third year after diagnosis, and whether any changes in weight and body fat varied by demographic, prognostic, and lifestyle factors in 514 women with incident Stage 0-IIIA breast cancer.
Patients were participants in the Health, Eating, Activity, and Lifestyle (HEAL) study. Weight and body fat (via dual-energy x-ray absorptiometry scans) were measured during the baseline visit and 2 years later at a follow-up visit. Analysis of covariance methods were used to obtain mean weight and body fat changes adjusted for potential cofounders.
Women increased their weight and percent body fat by 1.7 +/- 4.7 kg and 2.1% +/- 3.9%, respectively, from during their first year of diagnosis to during their third year of diagnosis. A total of 68% and 74% of patients gained weight and body fat, respectively. Greater increases in weight were observed among women diagnosed with a higher disease stage, younger age, being postmenopausal, and women who decreased their physical activity from diagnosis to up to 3 years after diagnosis (P for trend < .05).
Weight and body fat increased in the postdiagnosis period. Future research should focus on the effect of physical activity on weight and fat loss and breast cancer prognosis.

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Available from: Richard Neil Baumgartner
    • "Industrialized countries have higher exposure compared to non-industrialized nations. Immigration to industrialized countries and adopting a western lifestyle appears to increase the risk of developing breast cancer due to food additives or contaminants present in the diet and a higher exposure to environmental pollutants [1] [2] [3] [4]. Less than ten percent of the carcinogens we are exposed to have been tested and new chemicals are constantly found every year [5]. "
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    ABSTRACT: The increased number of women diagnosed with breast cancer in industrialized countries is raising the awareness of possible factors influencing this occurrence. The present work is based on a multi-layer transport model to analyze the concentration of toxins present in the breast ducts. The multi-layer model presented describes the transport of caffeine, cimetidine, aspirin and nicotine during the resting mammary gland period. Additionally, the dermal transport of drugs such as nicotine and aspirin into the resting mammary gland is analyzed. In a unique approach we also present the impact of introducing an external heat flux at the boundaries to increase the diffusion of these particles into the breast ducts. Our model predicts the movement of toxins and/or drugs within the resting mammary glands.
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    • "Current evidence suggests that breast cancer treatments, such as chemotherapy, lead to weight gain and increased adiposity, fatigue, physical inactivity, and negative alterations in components of metabolic syndrome (MetS) [4,10,27]. Metabolic syndrome (MetS), which is associated with increased risk of cardiovascular diseases and type 2 diabetes (6), is a cluster of risk factors including visceral adiposity, hyperglycemia, low serum high-density lipoprotein cholesterol, hypertriglyceridemia, and hypertension [28]. MetS is highly prevalent and present in at least 25% of American and European adults [29]. "
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