Systematic review of the Sugarbaker procedure for pseudomyxoma peritonei

Southampton Health Technology Assessments Centre, Wessex Institute for Health Research and Development, University of Southampton, Southampton, UK.
British Journal of Surgery (Impact Factor: 5.54). 02/2005; 92(2):153-8. DOI: 10.1002/bjs.4862
Source: PubMed


Pseudomyxoma peritonei, a rare progressive disease process within the peritoneum, is characterized by an abundance of mucinous fluid; if left untreated, the condition is fatal. The aim of this article is to assess the clinical effectiveness and costs of the Sugarbaker procedure for pseudomyxoma peritonei.
A systematic review of the literature up to April 2004 was undertaken, with modelling of costs.
Five retrospective case-series reports met the inclusion criteria. Survival after operation was approximately 95 per cent at 2 years and 60-68 per cent at 10 years, with 41-52 per cent of patients having no evidence of disease at the end of follow-up. A Monte Carlo simulation model estimated the marginal cost for one patient over a maximum of 5 years to be about pound 9700 (standard deviation pound 1300).
Evidence of the effectiveness of the Sugarbaker procedure for pseudomyxoma peritonei is limited in quantity and quality, but suggests there may be some benefit for patients. The marginal cost of the operation is about pound 9700, provided that trained and experienced staff are available to perform the procedure.

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Available from: Peter Davidson, Jul 28, 2014
    • "Pseudomyxoma peritonei is a disorder with low malignant potential, originates from the appendix and ovaries and spreads to the abdominal cavity causing mucinous ascites.[1] This condition is treated by cytoreduction and in recent times by the addition of hyperthermic intraperitoneal chemotherapy (HIPEC). "
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    • "The term PMP has been applied broadly and includes a heterogeneous group of pathological lesions from the benign to the borderline to the frankly malignant lesion.3,4 Ronnett et al have suggested a classification based on tumor pathology in which they place all PMP in three groups in order of decreasing prognosis: disseminated peritoneal adenomucinosis, peritoneal mucinous carcinoma with intermediate or discordant features, and peritoneal mucinous carcinoma.4 "
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