CAY-1, a novel antifungal compound from Cayenne pepper. Med Mycol

MycoLogics, Inc., Aurora, Colorado 80010, USA.
Medical Mycology (Impact Factor: 2.34). 03/2003; 41(1):75-81. DOI: 10.1080/714043901
Source: PubMed


CAY-1, a novel saponin from Capsicum frutescens (commercially known as cayenne pepper) was investigated to determine its in vitro antifungal activity, mechanism of action and mammalian cell cytotoxicity. CAY-1 was active against 16 different fungal strains, including Candida spp. and Aspergillus fumigatus [minimum inhibitory concentrations (MIC) ranging from 4 to 16 microg ml(-1)], and was especially active against Cryptococcus neoformans (90% inhibition at 1 microg ml(-1)). Synergistic activity was also observed between CAY-1 and amphotericin B against Candida albicans and A. fumigatus. No significant cytotoxicity was demonstrated when CAY-1 was tested against 55 mammalian cell lines at up to 100 microg ml(-1). Importantly, CAY-1 appears to act by disrupting the membrane integrity of fungal cells.

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    • "On this hypothesis, the antimicrobial activity of E. platyloba extract and its essential oil was observed against some different microorganisms including S. aureus, P. aeruginosa [6], Alcaligenes faecalis, S. marscescens, P. rettgeri, L. monocytogenes [25], C. albicans [2] [12] and dermatophytes [1]. In recent studies, the antimicrobial activity of E. platyloba was attributed to saponin, alkaloid and flavonoid [17] compounds, other studies exhibited that saponin , alkaloid and flavonoid have the significant antifungal activity [9] [14] [22] [26]. "
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