Article

Electroconvulsive therapy for malignant catatonia in childhood

Department of Pediatric Neurology, University Medical Center, 3508 AB Utrecht, The Netherlands.
Pediatric Neurology (Impact Factor: 1.7). 04/2005; 32(3):190-2. DOI: 10.1016/j.pediatrneurol.2004.10.004
Source: PubMed

ABSTRACT

A 13-year-old female is described with presumed viral encephalitis, who developed progressive catatonia, agitation, and autonomic dysfunction. The diagnosis of malignant catatonia was made, and the patient improved with electroconvulsive treatment. This article discusses features, causes, differential diagnosis, and treatment of malignant catatonia. In children with this syndrome, electroconvulsive treatment should be considered.

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  • No preview · Article · Jan 2005 · Journal of Ect
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    ABSTRACT: Autistic regression seems to occur in about a quarter of children with autism. Its cause is unknown. Late-onset autistic regression, that is, after 2 years of age, shares some features with catatonic regression. A working hypothesis is developed that some children with autistic regression suffer from early-onset catatonic regression. This hypothesis cannot be answered from current data and is difficult to address in clinical studies in the absence of definite markers of autistic and catatonic regression. Treatment implications are theoretical and involve the potential use of anticatatonic treatments for autistic regression. Focus is on electroconvulsive therapy (ECT)--an established but controversial treatment that is viewed by many, but not all, as the most effective treatment for severe, life-threatening catatonic regression. Clinical trials of ECT in early- or late-onset autistic regression in children have not been done yet. The effects of electroconvulsive seizures--the experimental analogue of ECT--should also be tested in gamma-aminobutyric acid-ergic animal models of autistic regression, autism, catatonia, and other neurodevelopmental disorders. Purkinje cell survival and neurogenesis are putative outcome measures in these models.
    Full-text · Article · Feb 2006 · International Review of Neurobiology
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    No preview · Article · Feb 2006 · International Review of Neurobiology
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