Article

Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea in children: a randomized double-blind placebo-controlled trial. Aliment Pharmacol Ther

Department of Pediatric Gastroenterology and Nutrition, The Medical University of Warsaw, Warsaw, Poland.
Alimentary Pharmacology & Therapeutics (Impact Factor: 5.73). 04/2005; 21(5):583-90. DOI: 10.1111/j.1365-2036.2005.02356.x
Source: PubMed

ABSTRACT

Co-treatment with Saccharomyces boulardii appears to lower the risk of antibiotic-associated diarrhoea in adults receiving broad-spectrum antibiotics.
To determine whether S. boulardii prevents antibiotic-associated diarrhoea in children.
A total of 269 children (aged 6 months to 14 years) with otitis media and/or respiratory tract infections were enrolled in a double-blind, randomized placebo-controlled trial in which they received standard antibiotic treatment plus 250 mg of S. boulardii (experimental group, n = 132) or a placebo (control group, n = 137) orally twice daily for the duration of antibiotic treatment. Analyses were based on allocated treatment and included data from 246 children.
Patients receiving S. boulardii had a lower prevalence of diarrhoea (> or =3 loose or watery stools/day for > or =48 h occurring during or up to 2 weeks after the antibiotic therapy) than those receiving placebo [nine of 119 (8%) vs. 29 of 127 (23%), relative risk: 0.3, 95% confidence interval: 0.2-0.7]. S. boulardii also reduced the risk of antibiotic-associated diarrhoea (diarrhoea caused by Clostridium difficile or otherwise unexplained diarrhoea) compared with placebo [four of 119 (3.4%) vs. 22 of 127 (17.3%), relative risk: 0.2; 95% confidence interval: 0.07-0.5]. No adverse events were observed.
This is the first randomized-controlled trial evidence that S. boulardii effectively reduces the risk of antibiotic-associated diarrhoea in children.

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    • "Thus it has become desirable to replace these conventional antioxidants with some natural antioxidative substances (Formanek et al., 2001). In this regard, natural antioxidant source Saccharomyces Boulardii is considered as a useful probiotics, and its oral administration could improve enzymatic activity and antioxidation functions and protect intestinal mucosa during transitional time in the intestine (Kotowska et al., 2005). Similarly in recent study, Bacillus subtilis was used as a probiotics and it has been illustrated through modern approaches in vivo studies that, probiotics support in antioxidation and enhance enzymatic activity during nutrients transportation in the intestine (Li et al., 2011a). "
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    ABSTRACT: The research was conducted to evaluate the feed supplementary effect of Saccharomyces boulardii and Bacillus subtilis on digestive enzyme activities, antioxidation capicity and blood homeostasis in broiler. A total of 300 day-old Sanhuang broilers (Chinese cross breed) were randomly divided into three groups with five replications in each group (n =20). The control group was fed basal diet contained antibiotic and experimental groups were supplemented with S. boulardii and B. subtilis in addition (1 × 10 8 cfu/kg) to basal diet for 72 days, respectively. The results revealed that activities of jejunal Na + -K + ATPase (ATP), lipase (LP) and Gamma glutamyl transpeptidase (γGT) concentration increased (P<0.05) in probiotic supplementary groups. Moreover, results from ileum showed high levels of γGT in B. subtilis supplemented group only. The serum glutathione peroxidase (GSH-PX), peroxidase (POD), glutathione (GSH), glutathione reductase (GR) and catalase (CAT) concentration were significantly higher, while there was a significant decrease (P <0.05) in malondialdehyde (MDA) content in supplementary groups. The blood biochemical analysis showed significant decrease in uric acid and triglycerides of S. boulardii and B. subtilis groups. Conversely, albumin and low-density lipoprotein concentration increased in S. boulardii and B. subtilis groups as compare to control. The present research revealed that, supplementation of S. boulardii and B. subtilis B10 could be applied to enhance digestive enzyme activities, antioxidation and blood profile of broilers. In addition it might be considered as a natural antioxidant feed additive for broiler. © 2013 Friends Science Publishers
    Full-text · Article · Mar 2013 · International Journal of Agriculture and Biology
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    • "Thus it has become desirable to replace these conventional antioxidants with some natural antioxidative substances (Formanek et al., 2001). In this regard, natural antioxidant source Saccharomyces Boulardii is considered as a useful probiotics, and its oral administration could improve enzymatic activity and antioxidation functions and protect intestinal mucosa during transitional time in the intestine (Kotowska et al., 2005). Similarly in recent study, Bacillus subtilis was used as a probiotics and it has been illustrated through modern approaches in vivo studies that, probiotics support in antioxidation and enhance enzymatic activity during nutrients transportation in the intestine (Li et al., 2011a). "

    Full-text · Article · Mar 2013 · International Journal of Agriculture and Biology
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    • "W Polsce Grupa Ekspertów na podstawie metaanaliz, badań z randomizacją prowadzonych na całym świecie, ustaliła stanowisko dotyczące zaleceń stosowania poszczególnych szczepów probiotycznych w profilaktyce biegunki związanej z antybiotykoterapią u dzieci [1]. Udokumentowano korzystne działanie ochronne w zapobieganiu biegunki związanej ze stosowaniem antybiotyków w zakresie szczepów bakterii, takich jak: Lactobacillus rhamnosus GG [19] [20], Saccharomyces boulardii [21], Lactobacillus rhamnosus (szczepy E/N, Oxy, Pen) [22] oraz zawartych w mleku modyfikowanym Bifidobacterium lactis Bb12 i Streptococcus thermophilus [23]. Według Grupy Polskich Ekspertów, dostępne na naszym rynku spożywcze produkty zawierających bakterie probiotyczne (kefiry, jogurty) nie wywierają działania protekcyjnego i nie zapobiegają biegunce związanej z antybiotykoterapią u dzieci [1]. "
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    ABSTRACT: The most frequent complication related with antibiotic therapy in small children is diarrhea. Clinical symptoms of Antibiotic-Associated Diarrhea (AAD) can vary from mild to life threatening, for example infection caused by Clostridium difficile. The aim of work is presentation the problem of antibiotic-associated diarrhea caused by Clostridium difficile in small children of the own observation.
    Preview · Article · Feb 2013 · Pediatria polska
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