Article

A stromal address code defined by fibroblasts

Rheumatology Research Group, Institute of Biomedical Research, MRC Center for Immune Regulation, University of Birmingham, UK, B15 2TT.
Trends in Immunology (Impact Factor: 10.4). 04/2005; 26(3):150-6. DOI: 10.1016/j.it.2004.11.014
Source: PubMed

ABSTRACT

To navigate into and within tissues, leukocytes require guidance cues that enable them to recognize which tissues to enter and which to avoid. Such cues are partly provided at the time of extravasation from blood by an endothelial address code on the luminal surface of the vascular endothelium. Here, we review the evidence that fibroblasts help define an additional stromal address code that directs leukocyte behaviour within tissues. We examine how this stromal code regulates site-specific leukocyte accumulation, differentiation and survival in a variety of physiological stromal niches, and how the aberrant expression of components of this code in the wrong tissue at the wrong time contributes to the persistence of chronic inflammatory diseases.

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Available from: Christopher D Buckley, May 17, 2014
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    • "Common mechanisms occur in these fibrotic processes that include persistent inflammation and local overproduction/activation of different cytokines (Ghosh and Vaughan, 2012; Huang and Ogawa, 2012). For example, infiltrating immune cells in DD excrete large amount of different cytokines, chemokines and growth factors, especially TGF-β1 (Baird et al., 1993), cytokine that induces typical phenotypic changes and inflammation (Parsonage et al., 2005; Lupher and Gallatin, 2006). Under such conditions, cells may acquire myofibroblast phenotype. "
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    • "Interestingly, homeobox (HOX) gene expression was differentially expressed according to the location where the fibroblasts were isolated. These data suggest that the geneexpression profile of adult fibroblasts may play a significant role in assigning positional identity within an organism and has lent support to the proposal of a stromal address code that can direct leukocyte behaviour (Parsonage et al., 2005). "

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