Courting a Cure for Fragile X

ArticleinNeuron 45(5):642-4 · April 2005with3 Reads
Impact Factor: 15.05 · DOI: 10.1016/j.neuron.2005.02.021 · Source: PubMed


    Fragile X syndrome is the most common heritable cause of mental retardation. Previous work has suggested that overactive signaling by group I metabotropic glutamate receptors (mGluRs) may be a mechanism underlying many of the disease symptoms. As a test of this theory, McBride et al. show that in a Drosophila model for Fragile X syndrome, treatment with mGluR antagonists can rescue short-term memory, courtship, and mushroom body defects.