Protection against group A streptococcal infection by vaccination with self-adjuvanting lipid core M protein peptides

ArticleinVaccine 23(17-18):2298-303 · April 2005with2 Reads
Impact Factor: 3.62 · DOI: 10.1016/j.vaccine.2005.01.041 · Source: PubMed

    Abstract

    We have investigated the lipid polylysine core peptide (LCP) system as a self-adjuvanting group A streptococcal (GAS) vaccine delivery approach. LCP constructs were synthesised incorporating peptides from the M protein conserved carboxy terminal C-repeat region, the amino terminal type-specific region and from both of these regions. Immunisation with the constructs without adjuvant led to the induction of peptide-specific serum IgG antibody responses, heterologous opsonic antibodies, and complete protection from GAS infection. These data indicate that protective immunity to GAS infection can be evoked using the self-adjuvanting LCP system, and point to the potential application of this system in human mucosal GAS vaccine development.