The Brown Adipose Cell: A Unique Model for Understanding the Molecular Mechanism of Insulin Resistance

ArticleinMini Reviews in Medicinal Chemistry 5(3):269-78 · April 2005with4 Reads
Impact Factor: 2.90 · DOI: 10.2174/1389557053175380 · Source: PubMed


    Type 2 diabetes mellitus (NIDDM) is a complex metabolic disease that occurs when insulin secretion can no longer compensate insulin resistance in peripheral tissues. At the molecular level, insulin resistance correlates with impaired insulin signaling. This review provides new insights into the molecular mechanisms of insulin action and resistance in brown adipose tissue (BAT) and pinpoints the role of BAT in the control of glucose homeostasis.