IAPs, RINGs and ubiquitylation

ArticleinNature Reviews Molecular Cell Biology 6(4):287-97 · May 2005with8 Reads
Impact Factor: 37.81 · DOI: 10.1038/nrm1621 · Source: PubMed


    The inhibitor of apoptosis (IAP) proteins all contain one or more baculoviral IAP repeat motifs, through which they interact with various other proteins. Many IAPs also have another zinc-binding motif, the RING domain, which can recruit E2 ubiquitin-conjugating enzymes and catalyse the transfer of ubiquitin onto target proteins. The number of targets of IAP-mediated ubiquitylation is increasing and recent results indicate that outcomes following ubiquitylation are tantalizingly complex. As well as regulating other proteins, the IAPs themselves are controlled by ubiquitin-mediated degradation.