6-(2-Furanyl)-9H-purin-2-amine derivatives as A(2A) adenosine antagonists

ArticleinBioorganic & Medicinal Chemistry Letters 15(8):2119-22 · May 2005with7 Reads
Impact Factor: 2.42 · DOI: 10.1016/j.bmcl.2005.02.031 · Source: PubMed


    Structure-activity relationships have been investigated through substitutions at the 9-position of the 2-amino-6-(2-furanyl) purine (5) to identify novel and selective A(2A) adenosine receptor antagonists. Several potent and selective antagonists were identified. In particular, compounds 20, 25, and 26 show very high affinity with excellent selectivity.