Article

Diverse taxa of cyanobacteria produce beta-N-methylamino-L-alanine, a neurotoxic amino acid. Proc Natl Acad Sci USA

Institute for Ethnomedicine, National Tropical Botanical Garden, Kalaheo, HI 96741, USA.
Proceedings of the National Academy of Sciences (Impact Factor: 9.67). 05/2005; 102(14):5074-8. DOI: 10.1073/pnas.0501526102
Source: PubMed

ABSTRACT

Cyanobacteria can generate molecules hazardous to human health, but production of the known cyanotoxins is taxonomically sporadic. For example, members of a few genera produce hepatotoxic microcystins, whereas production of hepatotoxic nodularins appears to be limited to a single genus. Production of known neurotoxins has also been considered phylogenetically unpredictable. We report here that a single neurotoxin, beta-N-methylamino-L-alanine, may be produced by all known groups of cyanobacteria, including cyanobacterial symbionts and free-living cyanobacteria. The ubiquity of cyanobacteria in terrestrial, as well as freshwater, brackish, and marine environments, suggests a potential for wide-spread human exposure.

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    • "The extraction procedure was based on methods previously described for extraction of free BMAA (e.g. Cox et al., 2005). For detection, a new HILIC UHPLCeMS/MS method was developed based on direct detection of BMAA, i.e. without using derivatization. "
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    • "Deregulation of PP activity can lead to the changes in signal transduction and disturbed balance in cellular homeostasis. In Baltic cyanobacteria, two neurotoxic metabolites have also been detected: anatoxin-a (Rantala-Ylinen et al., 2011) and β-N-methylamino-L-alanine (BMAA) (Cox et al., 2005; Jonasson et al., 2010). Anatoxin-a irreversibly binds to the nicotinic acetylcholine receptor . "
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    Full-text · Article · Aug 2015 · European Journal of Phycology
    • ".BMAAanditsisomersincultivatedcyanobacteriaandother microalgae Cyanobacteriahavebeenthefirstorganismssuspectedtobe BMAA-producers(Coxetal.,2005).Thedominanceofdiatomsand dinoflagellatesinsomemarineecosystems,concurrentlywiththe occurrenceofBMAAinmollusks,hasledsomegroupstoinvesti- gatethepotentialproductionofBMAAbytheseabundantmicroalgalspecies(Jiangetal .,2014a;JiangandIlag,2014;Lageetal., 2014),increasingthenumberofpotentialBMAA-producing microalgae.WescreenedfoursstrainsofthecyanobacteriaSynechococcus ,previouslyisolatedfromThaulagoonaswellasseveral other,emblematicprotistsisolatedfromthislagoon:O.tauri,and twostrainsofA.catenella.AsdiatomswereabundantinThau lagoon,includingseveralreportsofChaetocerossp.,wealso "
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    No preview · Article · Aug 2015 · Marine environmental research
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