Follow-up of infants given measles vaccine at 6 months of age: Antibody and CMI responses to MMRII® at 15 months of age and antibody levels at 27 months of age

Department of Pediatrics, University of Alberta, Edmonton, Canada.
Vaccine (Impact Factor: 3.62). 06/2005; 23(25):3247-55. DOI: 10.1016/j.vaccine.2005.01.092
Source: PubMed


The worldwide elimination of measles is an important target. In developed countries, to control measles outbreaks, immunization from 6 months of age is recommended. In this study, infants (n = 290) who were (1) born to mothers with natural immunity or to vaccinated mothers and (2) previously immunized with Connaught (CLL) or AIK-C measles vaccine at 6 months of age, were evaluated for measles immunity before and after measles-mumps-rubella (MMRII at 15 months of age. Eight weeks after MMRII, 98.9% of infants were seropositive by enzyme immunoassay (EIA) and 70% demonstrated measles specific cellular immunity by blast transformation (BT) of lymphocytes. At 27 months of age, 98.4% of infants had protective antibody levels by plaque reduction neutralization (PRN) test. These results suggest that AIK-C and CLL vaccines elicit durable protective immunity in young infants when used in early immunization programs.

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