Cardiac Hamartoma. Case Report and Literature Review

Servicio de Cardiología, Hospital Virgen de la Macarena, Sevilla, España.
Revista Espa de Cardiologia (Impact Factor: 3.79). 05/2005; 58(4):450-2. DOI: 10.1016/S1885-5857(06)60675-0
Source: PubMed


Primary cardiac tumors are infrequent and usually benign. They can manifest as dyspnea, chest pain, palpitations, sudden death, peripheral embolism, cyanosis, or general symptoms. They are sometimes an incidental finding in an asymptomatic patient. We describe a 33-year-old man who was seen because of dyspnea and palpitations. Transthoracic echocardiography revealed, on the lateral wall of the left ventricle, an intramyocardial mass that was successfully resected surgically. The pathologic diagnosis was hamartoma of mature cardiac myocytes. We discuss the usefulness of imaging techniques for identifying cardiac masses.

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Available from: José M Cruz-Fernández
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    • "Dinh et al. [4] 2001 1 Surgery ● ● Chu et al. [5] 2004 1 Surgery ● ● Gilman et al. [6] 2005 1 Surgery ● ● Quesada et al. [7] 2005 1 Surgery ● ● Fealey et al. [8] 2008 4 Autopsy (2 pts), surgery (1 pt), biopsy (1 pt) Movahedi et al. [9] 2008 1 Surgery Menon et al. [10] "

    Full-text · Article · Oct 2012 · International journal of cardiology
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    • "Hamartomas of mature cardiac myocytes are rare and, to our knowledge, have been reported in only 8 patients [1] [2] [3] [4] [5] [6]. As such, their clinicopathologic spectrum is not yet well defined in the literature. "
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    ABSTRACT: Only 8 cases of hamartomas of mature cardiac myocytes have been reported. The aim of the study was to describe 7 new cases and provide clinicopathologic correlation. Our anatomical pathology database was searched for all cases of cardiac hamartoma, of which 7 represented mature myocyte type. Medical records were reviewed for clinical information, and microscopic slides were evaluated for extent of characteristics. Five males and 2 females ranged in age from 6 months to 74 years (mean, 23 years). There were 11 ventricular hamartomas (8 left free wall, 2 right free wall, 1 septum). Death in 3 infants was unrelated to incidental hamartomas discovered at autopsy. A 10- and 16-year-old were asymptomatic but had abnormal electrocardiogram (ECG) results, which led to detection of cardiac masses by imaging studies. Two adult males had only mild coronary disease angiographically. The 57-year-old, who died suddenly, had a 7-year history of abnormal ECG results. The 74-year-old, who died after aortic surgery, had a 3-year history of chest discomfort. Their hamartomas were identified at autopsy and contributed to sudden death in 1. Microscopically, all hamartomas were involved by myocyte hypertrophy and disarray, without inflammation or calcification. Myocyte vacuolization and venular dilatation occurred only in the pediatric cases, and interstitial adipose tissue only affected 1 adult. In conclusion, hamartomas of mature cardiac myocytes may be detected at any age. They primarily affect males, arise predominantly in the left ventricle, are asymptomatic, may have nonspecific ECG findings, and rarely may be associated with sudden death. Microscopic findings in infants differ from older patients.
    Full-text · Article · Aug 2008 · Human pathology
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    ABSTRACT: Thermal effects on wavelength switching dynamics are investigated for a wideband laser. For frequency shift keying (FSK) applications it has been shown that the laser phase current must be switched every 30 ns or in other words modulated at over 35 MHz, to achieve full range frequency dither. Alternatively FSK as low as 5 MHz is possible with a 10% loss of frequency excursion. In this paper, thermal effects on the FSK modulation and wavelength switching dynamics are investigated for a grating-assisted co-directional coupler with sampled grating reflector (GCSR) laser with the phase section.
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