Invasive cribriform carcinoma with extensive microcalcifications in the male breast

Department of Clinical Laboratory, National Hospital Organization Shikoku Cancer Center, Horinouchi 13, Matsuyama, Ehime 790-0007, Japan.
Breast Cancer (Impact Factor: 1.59). 02/2005; 12(2):145-8. DOI: 10.2325/jbcs.12.145
Source: PubMed


Invasive cribriform carcinoma (ICC) is a rare, unique type of invasive breast carcinoma that exhibits a cribriform pattern in the majority of the invasive component and is associated with an excellent prognosis. Only one male patient with ICC has been previously reported. Mammography studies often suggest that ICC contains microcalcifications, but the histological finding of extensive microcalcification has only been reported in one patient with ICC. Here we report a male patient diagnosed with ICC and exhibiting histologically confirmed extensive microcalcification is reported. The patient was a 64-year-old Japanese man in whom a breast tumor was detected during an annual check up. Mammography demonstrated a circumscribed high-density mass with microcalcifications. Breast-conserving surgery with axillary node dissection was performed. The tumor was located in the subareolar region of his left breast. The excised tumor had a maximum diameter of 1.0 cm, and no signs of invasion to extramammary tissue were observed. Histologically, the tumor cells were arranged in a cribriform pattern with invasive and non-invasive components. High-grade carcinoma or tubular carcinoma components were not observed. Extensive calcification was seen within the cribriform spaces. Immunohistological staining revealed that the cribriform spaces did not contain basement membrane material, and the tumor cells had not differentiated into basaloid cells or lactational mammary epithelium. The patient is presently free from local recurrence or metastasis 7 months after undergoing surgery.

Download full-text


Available from: Norihiro Teramoto
  • [Show abstract] [Hide abstract]
    ABSTRACT: The male breast is normally a rudimentary structure composed of small ducts and fibrous tissue with variable amounts of periductal fat, identical histologically to the breast of prepubertal females [1]. In the absence of estrogenic stimulation, lobules are not seen. The incidences in males of absent breasts or nipples and of supernumerary nipples are identical to the incidences in females [2]. In the absence of enlargement, breast tissue in the male is confined to the area directly behind the areola; therefore, clinical breast examination (CBE) is very easy in males and usually can be performed with just one or two examining fingers.
    No preview · Article · Jan 2010
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Invasive cribriform carcinoma is a rare type of invasive breast carcinoma with an excellent prognosis and is characterized by a cribriform histological pattern. However, there is scant information about the radiologic features of invasive cribriform carcinoma of the breast. We report a case of invasive cribriform carcinoma of the breast with radiologic features including MR imaging findings.
    Preview · Article · Jan 2011
  • [Show abstract] [Hide abstract]
    ABSTRACT: The purpose of this series was to evaluate the sonographic features of invasive cribriform carcinoma of the breast. Between 2004 and 2010, 3 patients had confirmed invasive cribriform carcinoma of the breast in our institution, and all of them underwent sonography. Sonograms showed masses with an oval (n = 2) or irregular (n = 1) shape, partially microlobulated (n = 2) or well-circumscribed (n = 1) margins, and a hypoechoic (n = 2) or an isoechoic (n = 1) internal echo texture. Sonographic assessments were classified as Breast Imaging Reporting and Data System category 4 in all 3 cases. Although invasive cribriform carcinoma is a rare breast malignancy, awareness of its sonographic features will be helpful for the diagnosis.
    No preview · Article · May 2011 · Journal of ultrasound in medicine: official journal of the American Institute of Ultrasound in Medicine
Show more