Lipid response to a low-fat diet with or without soy is modified by C-reactive protein status in moderately hypercholesterolemic adults

Department of Nutritional Sciences, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA.
Journal of Nutrition (Impact Factor: 3.88). 05/2005; 135(5):1075-9.
Source: PubMed


Recent evidence suggests that individuals with high concentrations of C-reactive protein (CRP), a marker of inflammation, are less responsive to cholesterol-lowering diets. CRP concentrations are increased by oral estrogen; however, the effect of soy phytoestrogens on inflammation has not been studied comprehensively, especially in women receiving hormone replacement therapy (HRT). This study was conducted to determine whether adding soy to a low-fat, high-fiber diet affects CRP and interleukin (IL)-6, and to examine the association between CRP levels and lipid response in moderately hypercholesterolemic adults (men = 18, postmenopausal women = 14; 6 receiving HRT). After a 3-wk run-in period with consumption of a Step I diet (27% total fat, 7% saturated fat, 275 mg cholesterol), participants were randomly assigned to diets containing 25 g/d soy protein (+ 90 mg/d isoflavones) or 25 g/d milk protein for 6 wk in a crossover design. Lipids and lipoproteins, CRP, and IL-6 were measured at the end of each diet and participants were categorized into high (>3.5 mg/L) or low CRP groups based on a median split. The addition of soy or milk protein to the Step I diet did not affect lipids or inflammatory markers. Regardless of protein source, those with low CRP exhibited significant decreases in LDL cholesterol (-3.5%) and the LDL:HDL cholesterol ratio (-4.8%), whereas those with high CRP had significant increases in LDL cholesterol (+4.8%), the LDL:HDL cholesterol ratio (+5.2%), apolipoprotein B (+3.8%), and lipoprotein(a) (+13.5%) compared with the run-in diet. These results suggest that inflammation may not only attenuate lipid responses, but also aggravate dyslipidemia in hypercholesterolemic subjects consuming a cholesterol-lowering diet.

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Available from: Sheila West, Jan 07, 2015
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    • "Obesity, influenced by environmental and genetic factors, is one of the important factors in the etiology of metabolic syndrome, cardiovascular disease (CVD), and cancer [1] [2] [3]. Obesity is related to increased level of inflammatory markers such as CRP (C-reactive protein) that are associated with metabolic syndrome [4]. According to evidence of 2005, 937 and 396 million people around the world were obese and overweight, respectively [5]. "
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    ABSTRACT: Background. Adiponectin, an adipokine secreted from adipose tissue, has antiobesity, anti-insulin resistance, and anticancer roles. The present study aimed to review the epidemiologic evidence about the association between adiponectin and cancers. Method. We searched in PubMed from 2002 to October 2011 by using the following key words: cancer, malignancy, cell proliferation, and adiponectin. Finally, 45 articles were recruited to review in the present paper. Findings. Several findings suggested inverse association between concentration of hormone and breast cancer risk. Low levels of adiponectin increase the risk of endometrial cancer in women. Adiponectin levels were significantly associated with prostate cancer in men. It seems that there is an inverse relationship between levels of adiponectin or its gene and colorectal cancer. Significant association between hormone and pancreatic cancer was found. Conclusion. Several findings suggested the negative correlation between adiponectin and risk of cancers. This relationship was more elucidated by the correlation between the hormone with obesity and insulin resistance. Suppression of growth and proliferation of cancer cells by adiponectin were explained via several mechanisms.
    Preview · Article · Nov 2012
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    • "administering soy protein isolate or isolated isoflavones concur with the absence of effect on CRP shown in the present study (Teede et al., 2004; D'Anna et al., 2005; Hilpert et al., 2005; Yildiz et al., 2005; Hanson et al., 2006; Ryan- Borchers et al., 2006). Regardless of intervention length (1 month to 3 years), vehicle of administration (soy protein isolate or isoflavone tablets) or isoflavone dose (10–129 mg), significant effects on CRP were not observed in these studies. "
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