Susceptibility of bovine mesenchymal stem cells to bovine herpesvirus 4

Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Facoltà di Medicina Veterinaria, Via del Taglio 8, 43100 Parma, Italy.
Journal of Virological Methods (Impact Factor: 1.78). 09/2005; 127(2):168-70. DOI: 10.1016/j.jviromet.2005.02.019
Source: PubMed


Bovine herpesvirus 4 (BoHV-4) is a gamma herpesvirus with no clear disease association. Previous studies have demonstrated that macrophages can harbour persistent BoHV-4. Since mesenchymal stem cells in bone marrow regulate the differentiation and proliferation of adjacent haematopoietic precursors, such as macrophages, the interaction between BoHV-4 and mesenchymal stem cells was investigated. Primary bovine mesenchymal stem cells were highly permissive to support full replication of BoHV-4. This finding could be considered a new important step in studies on the potential pathogenesis related to BoHV-4.

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    • "In the cattle, bone marrow MSCs from iliac crest have been isolated and differentiated into osteocytes and were used for virological experiments (Donofrio et al. 2005). "
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