Survival rate in patients with hepatocellular carcinoma: A retrospective analysis of 389 patients

Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule, Carl Neuberg Str 1, Hannover 30625, Germany.
British Journal of Cancer (Impact Factor: 4.84). 05/2005; 92(10):1862-8. DOI: 10.1038/sj.bjc.6602590
Source: PubMed


Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. However, treatment options are limited and often inefficient. The aim of this study was to determine current survival rates for patients diagnosed with HCC and to identify prognostic factors, which will help in choosing optimal therapies for individual patients. A retrospective analysis of medical records was performed on 389 patients who were identified through the central tumour registry at our institution from 1998 to 2003. Clinical parameters, treatments received and survival curves from time of diagnosis were analysed. Overall median survival was 11 months. Liver cirrhosis was diagnosed in 80.5% of all patients. A total of 170 patients received transarterial chemoembolisation (TACE) and/or percutaneous ethanol injections (PEI) with a median survival rate of 16 months for patients receiving TACE, 11 months for patients receiving PEI and 24 months for patients receiving TACE followed by PEI. Independent negative prognostic parameters for survival were the presence of portal vein thrombosis, advanced liver cirrhosis (Child-Pugh score B or C) and a score of >2. This study will help to estimate survival rates for patients with HCC according to their clinical status at diagnosis and the treatments received.

Download full-text


Available from: Frank Papendorf, Apr 14, 2015
  • Source
    • "TACE has been shown to improve survival of patients with HCC in a randomized control trial [16]. It has been reported that the 3- and 5-year survival rates of patients receiving TACE was 26-47% [16,17,30,31] and 16-26% [32-34], respectively. Because of the low incidence of BCS patients with HCC, no studies with a large patient population have been investigated the long-term survival of BCS patients with HCC receiving TACE. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Budd--Chiari syndrome (BCS) often leads to hepatocellular carcinoma (HCC). Transcatheter arterial chemoembolization (TACE) has been increasingly used to treat BCS patients with HCC. The purposes of this study were to illustrate imaging features in BCS patients with HCC, and to analyze the effects of TACE BCS on BCS patients with HCC. 246 consecutive patients with primary BCS were retrospectively studied. 14 BCS patients with HCC were included in this study. BCS were treated with angioplasty and/or stenting, and HCC were managed with TACE. Imaging features on ultrasonography, CT, MRI, and angiography and the serum AFP level were analyzed. Inferior vena cava block and stricture of hepatic venous outflow tract more frequently occurred. Portal vein invasion was found in only 2 patients (14.2%). Imaging studies showed that most nodules of HCC were near the edge of liver, irregular, more than 3 cm in diameter, heterogeneous mass and solitary (<=3 nodules). HCC in patients associated with BCS was isointense or hypointense in nonenhanced CT images, and exhibited heterogeneous enhancement during the arterial phase and washout during the portal venous phase on enhanced CT and MRI. The serum AFP level significantly declined after TACE treatment. BCS patients with inferior vena cava block and stricture of hepatic venous outflow tract seems to be associated with HCC. A single, large, irregular nodule with a peripheral location appears to be HCC. TACE can effectively treat HCC in BCS patients.
    Full-text · Article · Jun 2013 · BMC Gastroenterology
  • Source
    • "These findings, as well as the fact that HCC predominantly arose in a cirrhotic liver (83.7%) are in line with most European HCC studies. In these studies, alcohol and HCV respectively have repeatedly been identified as the two leading etiologic factors for HCC in Europe [25], [26]. In our cohort of German HCC patients chronic alcohol abuse was the most frequent single risk factor (44%) followed by HCV (18.8%) supporting the data from a large study on epidemiology of HCC in southern Germany [27]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: HCC is diagnosed in approximately half a million people per year, worldwide. Staging is a more complex issue than in most other cancer entities and, mainly due to unique geographic characteristics of the disease, no universally accepted staging system exists to date. Focusing on survival rates we analyzed demographic, etiological, clinical, laboratory and tumor characteristics of HCC-patients in our institution and applied the common staging systems. Furthermore we aimed at identifying the most suitable of the current staging systems for predicting survival.
    Full-text · Article · Oct 2012 · PLoS ONE
  • Source
    • "Hepatocellular carcinoma (HCC) represents the third leading cause of cancer related death worldwide. Only a minority of patients is eligible for potential curative treatments such as surgical resection, liver transplantation and local ablative therapies [1,2]. Therapeutic options for patients with advanced HCC are limited. "
    [Show abstract] [Hide abstract]
    ABSTRACT: The sole effective option for patients with advanced HCC is sorafenib and there is an urgent need to develop new therapeutic approaches. Immunotherapy is a promising option that deserves major investigation. In this open label, single arm clinical trial, we analyzed the effect of a low dose cyclophosphamide treatment in combination with a telomerase peptide (GV1001) vaccination in patients with advanced HCC. 40 patients with advanced HCC were treated with 300 mg/m2 cyclophosphamide on day -3 followed by GM-CSF + GV1001 vaccinations on days 1, 3, 5, 8, 15, 22, 36 followed by 4-weekly injections. Primary endpoint of this phase II trial was tumor response; secondary endpoints evaluated were TTP, TTSP, PFS, OS, safety and immune responses. None of the patients had a complete or partial response to treatment, 17 patients (45.9%) demonstrated a stable disease six months after initiation of treatment. The median TTP was 57.0 days; the median TTSP was estimated to be 358.0 days. Cyclophosphamide, GV1001 and GM-CSF treatment were well tolerated and most adverse events, which were of grade 1 or 2, were generally related to the injection procedure and injection site reactions. GV1001 treatment resulted in a decrease in CD4+CD25+Foxp3+ regulatory T cells; however, no GV1001 specific immune responses were detected after vaccination. Low dose cyclophosphamide treatment followed by GV1001 vaccinations did not show antitumor efficacy as per tumor response and time to progression. Further studies are needed to analyze the effect of a combined chemo-immunotherapy to treat patients with HCC. NCT00444782.
    Full-text · Article · Apr 2010 · BMC Cancer
Show more