Analyses of prognostic indices of chronic liver failure caused by hepatitis virus

Department of Obstetrics and Gynecology, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China.
World Journal of Gastroenterology (Impact Factor: 2.37). 06/2005; 11(18):2841-3.
Source: PubMed


To analyze the related indices about the prognoses of chronic liver failure caused by hepatitis virus.
Retrospectively reviewed 320 cases of chronic liver failure caused by hepatitis viruses. An improved group and an ineffective group (IG) were made to compare and analyze their clinical manifestations, laboratory examination indices and complications. Logistic regression was also carried out.
There were significant differences (P<0.05) between the improved group and the IG upon such indices as age, bilirubin, prothrombin time, albumin, alpha fetoprotein, the size of liver and complications (P<0.05). The regression formula was as follows: P = 1/(1+e(-y)) (y = 1.7262-0.0948X(1)+2.9846X(2)+0.6992X(3)+1.6019X(4)+ 2.0398X(5)). (Note: X(1)-Prothrombin activity; X(2)-digestive tract hemorrhage; X(3)-hepatic encephalopathy; X(4)-hepatorenal syndrome; X(5)-pulmonary infection.).
Laboratory examination such as bilirubin, prothrombin time and alpha fetoprotein can be regarded as indices of the prognoses of chronic liver failure caused by hepatitis. Moreover, the regression equation can evaluate prognoses more comprehensively and direct our treatments.

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    • "In order to improve the study efficiency and control for confounding factors, the case and control subjects were matched by sex, age, and MELD score (frequency matching). In China, as a result of the high prevalence of hepatitis B virus (HBV), chronic HBV infection is the most common cause of liver failure (17, 18). Inclusion criteria included: 1) Hepatitis B virus-related acute-on-chronic liver failure 2) Patients who had their first episode of Grade II-IV HE in the hospital for at least six days were included in the study. "
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