Fc RIIIb and Complement Component C7 Codeficiency in a Patient with Recurrence of Fulminant Meningococcal Septic Shock

University of Amsterdam, Amsterdamo, North Holland, Netherlands
Clinical Infectious Diseases (Impact Factor: 8.89). 07/2005; 40(11):1679-83. DOI: 10.1086/430065
Source: PubMed


Individuals with deficiencies of the late components of complement exhibit a susceptibility to the recurrence of meningococcal
disease with a usually mild clinical presentation. We report the recurrence of fulminant meningococcal disease in a complement
component C7–deficient patient. We found a total deficiency of FcγRIIIb on neutrophils, which could partially explain the
unusually severe clinical presentation.

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