Partial Normalization of Serum Brain-Derived Neurotrophic Factor in Remitted Patients after a Major Depressive Episode

ArticleinNeuropsychobiology 51(4):234-8 · February 2005with10 Reads
DOI: 10.1159/000085725 · Source: PubMed
Abstract
We had previously reported decreased serum brain-derived neurotrophic factor (BDNF) levels in depressed patients. In the present study, we tested the hypothesis that antidepressant treatment would normalize serum BDNF levels, at least in a subgroup of patients. Major depressed patients (15 females and 11 males) diagnosed according to DSM-IV criteria and healthy controls (13 females and 13 males) participated in this study. Serum BDNF was assayed with the ELISA method for depressed and remitted patients and the severity of depression was evaluated with the Montgomery-Asberg Depression Rating Scale. An analysis of variance showed that treatment had an effect [F(1, 24) = 4.46, p = 0.045] on the normalization of serum BDNF levels. We also found a correlation between the severity of depression (r = 0.51, p = 0.008), the pretreatment BDNF levels (r = 0.62, p = 0.001) and the difference in serum BDNF levels after antidepressant treatment. These results suggest that antidepressant treatment has a positive effect on serum BDNF levels and support the hypothesis of neurotrophic factor involvement in affective disorders.
    • "Further, enhanced BDNF expression has been found in the nucleus accumbens of individuals with depression [44] . These alterations were reversed following antidepressant treatment [45, 46]. In experimental models, BDNF levels decreased in the hippocampus and frontal cortex [20, 21], whereas they increased in the nucleus accumbens and VTA [22, 47], which might suggest different roles of BDNF in different brain structures [27]. "
    [Show abstract] [Hide abstract] ABSTRACT: Previous studies have identified the beneficial effects of electroacupuncture (EA) on motor behaviors in Parkinson’s disease (PD). However, the role and potential mechanisms of EA in PD-associated depression remain unclear. In the present study, a rat model of PD with unilateral 6-hydroxydopamine (6-OHDA) lesions in the medial forebrain bundle was treated using EA for 4 weeks. We found that 100 Hz EA improved several motor phenotypes. In addition, tyrosine hydroxylase (TH) immunohistochemical analysis showed that EA had a minimal impact on the TH-positive profiles of the ipsilateral ventral tegmental area. Compared with the 6-OHDA group, long-term EA stimulation significantly increased sucrose solution consumption and decreased immobility time in the forced swim test. EA treatment did not alter dopamine, norepinephrine, and serotonin levels in the striatum and hippocampus. Noticeably, EA treatment reversed the 6-OHDA-induced abnormal expression of brain-derived neurotrophic factor (BDNF) and tropomyosin-related kinase B (TrkB) in the midbrain and hippocampus. These results demonstrate that EA at 100-Hz possesses the ability to improve depressive-like symptoms in PD rats, which is, at least in part, due to the distinct effect of EA on the mesostriatal and mesocorticolimbic dopaminergic pathways. Moreover, BDNF seems to participate in the effect of EA in PD.
    Full-text · Article · Jul 2016
    • "The findings suggest that levels of serum BDNF and cortisol are reciprocal in nature in patients with depression. In this study, rise in BDNF levels was observed in the Yoga group, which is consistent with the previous antidepressant related studies on serum BDNF levels (Aydemir, Deveci, & Taneli, 2005; Aydemir, Deveci, Taskin, Taneli, & Esen-Danaci, 2007; Gervasoni et al., 2005; Shimizu et al., 2003 ). Patients getting yoga therapy , either with drugs or solely, had better reductions in cortisol levels. "
    [Show abstract] [Hide abstract] ABSTRACT: Depression is associated with low serum Brain Derived Neurotrophic Factor (BDNF) and elevated levels of serum cortisol. Yoga practices have been associated with antidepressant effects, increase in serum BDNF, and reduction in serum cortisol. This study examined the association between serum BDNF and cortisol levels in drug-naïve patients with depression treated with antidepressants, yoga therapy, and both. Fifty-four drug-naïve consenting adult outpatients with Major Depression (32 males) received antidepressants only (n = 16), yoga therapy only (n = 19), or yoga with antidepressants (n = 19). Serum BDNF andcortisol levels were obtained before and after 3 months using a sandwich ELISA method. One-way ANOVA, Chi-square test, and Pearson's correlation tests were used for analysis. The groups were comparable at baseline on most parameters. Significant improvement in depression scores and serum BDNF levels, and reduction in serum cortisol in the yoga groups, have been described in previous reports. A significant negative correlation was observed between change in BDNF (pre-post) and cortisol (pre-post) levels in the yoga-only group (r = -0.59, p = 0.008). In conclusion, yoga may facilitate neuroplasticity through stress reduction in depressed patients. Further studies are needed to confirm the findings and delineate the pathways for these effects.
    Full-text · Article · May 2016
    • "In humans, lower serum BDNF levels have been found in patients with major depressive disorder (MDD) [3,4], bipolar disorder [5,6], schizophrenia [7,8], eating disorders [9,10], obsessive-compulsive disorder [11], and alcohol dependence [12] . In most studies involving MDD, serum BDNF levels have been shown to correlate negatively with disease severity131415, and antidepressant treatment increases serum levels of BDNF [14,16171819 . However, there is a large overlap between BDNF levels in the serum of depressed patients and controls [15] , and levels are not decreased in all depressed patients. "
    [Show abstract] [Hide abstract] ABSTRACT: Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors. Previous studies have demonstrated lower serum BDNF levels in patients with major depressive disorder (MDD) and reported an association between BDNF levels and depression-related personality traits in healthy subjects. The aim of the present study was to explore for a possible association between peripheral BDNF levels and personality traits in patients with MDD. In this cross-sectional study, a total of 123 inpatients with MDD (Diagnostic and Statistical Manual for Mental Disorders, 4th edition) at the Juntendo University Koshigaya Hospital were recruited. Serum levels of BDNF were measured. Personality traits were assessed using the 125-item short version of the Temperament and Character Inventory (TCI). Multiple regression analysis adjusted for age, sex, body mass index, dose of antidepressant, and depression severity showed that TCI Self-Directedness (SD) scores were negatively associated with serum BDNF levels (β = -0.23, p = 0.026). MDD patients who have low SD did not show the reduction in serum BDNF levels that is normally associated with depressive state. Our findings suggest that depression-related biological changes may not occur in these individuals.
    Full-text · Article · Dec 2015
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