Bacopa Monniera, A reputed nootropic plant: An overview

University of Naples Federico II, Napoli, Campania, Italy
Phytomedicine (Impact Factor: 3.13). 05/2005; 12(4):305-17. DOI: 10.1016/j.phymed.2003.12.008
Source: PubMed


Bacopa monniera (BM), a traditional Ayurvedic medicine, used for centuries as a memory enhancing, anti-inflammatory, analgesic, antipyretic, sedative and antiepileptic agent. The plant, plant extract and isolated bacosides (the major active principles) have been extensively investigated in several laboratories for their neuropharmacological effects and a number of reports are available confirming their nootropic action. In addition, researchers have evaluated the anti-inflammatory, cardiotonic and other pharmacological effects of BM preparations/extracts. Therefore, in view of the important activities performed by this plant, investigation must be continued in the recently observed actions described in this paper. Moreover, other clinical studies have to be encouraged, also to evidence any side effects and possible interactions between this herbal medicine and synthetic drugs.

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Available from: Francesca Borrelli, Jul 17, 2014
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    • "). Brahmi may regulate antibody production by augmenting both Th1 and Th2 cytokine production and regular use of Brahmi along with other herbs has been suggested to stimulate body immune system against AIDS and generalized weakness (Stough et al., 2001; Yamada et al., 2011) and also prevents the rate of depletion of blood acetylcholine in aged people and induced lipid peroxidation (Russo and Borrelli, 2005; Rajani, 2008). "
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    ABSTRACT: The different explants (leaves, nodes and internodes) of Bacopa monniera L. were cultured on MS basal medium without growth regulators (GR) to assess the effect of an antibiotic (Trimethoprim-TMP) and an antifungal agent (Bavistin-BVN). Direct shoot regeneration without callus formation was induced by culturing explants on MS medium without GR. TMP at 50 mg/l was found optimum for shoot regeneration from leaf explants. Higher concentration of TMP did not show any improvement more than 50 mg/l on shoot regeneration in nodal explants. BVN at 100 mg/l had the optimum effect on regeneration from internodal and leaf explants, but nodal explants showed better regeneration on 150 mg/l BVN. The adventitious shoot regenerated from vertically placed nodes on medium containing 150 mg/l BVN and horizontally placed nodal segments showed regeneration at 100 mg/l. Increasing upto 200 mg/l TMP concentration significantly promoted adventitious shoot bud regeneration in intermodal explants. The combination of TMP and BVN significantly suppressed root regeneration at higher concentration in internodes and leaf explants, while TMP at lower concentration showed better root regeneration as compared to culture grown on GRfree MS-medium. Trimethoprim and Bavistin exhibited cytokinin-like activity as they promoted axillary shoots from node and adventitious shoot buds regeneration on the surface of all explants.
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    • "Several studies using the standardized CDRI08 extract have shown that EBm improves cognitive function particularly in the elderly [6] [7] [8]. Animal and in vitro studies using the standardized extract CDRI08 have revealed promising results to elucidate EBm's antioxidant properties (e.g., [9] [10] [11] [12]). The aim of this review is to examine the evidence for EBm as a potential therapeutic antioxidant to reduce oxidative stress in the aging brain and as a mechanism by which it may improve cognition. "
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    • "may impact human cognition in an acute manner and also serve to ameliorate cognitive decline when consumed over longer periods (Russo and Borrelli 2005). A growing number of randomized controlled trials in healthy middle-aged to elderly adults have demonstrated that consumption of standardized extracts of BM can improve components of human cognition (Calabrese et al. 2008; Morgan and Stevens 2010; Stough et al. 2008; Stough et al. 2001; Stough et al. 2012). "

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