Functional-morphologic aspects of changes of mucosal gingiva microcirculatory bed vessels in experimental gingivitis against the background of hypercholesterolemia
The study of mucosal gingiva microcirculatory bed in conditions modeling the change of vascular wall permeability that promotes cell migration and plasmorrhagia. The experiments were made on 3 groups of chinchilla rabbits--body weight 1,7-2,5 kg: I-experimental gingivitis (10 animals); II-experimental hypercholesterolemia--the rabbits received aterogenic diet (0,3 g/kg of cholesterol) (10 animals). Two month after the aterogenic diet, gingivitis was modelled against the background of hypercholesterolemia (control for group II). IV-series--conditionally "normal"--5 rabbits. The light-optic and electron microscopic studies have revealed significant changes in extracellular matrix and gingiva mucous cells as well as in microcirculatory bed components in hypercholesterolemia. Hypercholesterolemia damages endotheliocytes, subendothelial zone, basal membrane abd changes permeability. The contact of lymphocytes and plasmocytes with the vascular wall confirms the trigger role of the vascular factor in damaging of periodontal complex.
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.