Inhibitors of HCVNS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid

ArticleinBioorganic & Medicinal Chemistry Letters 15(11):2812-8 · July 2005with9 Reads
Impact Factor: 2.42 · DOI: 10.1016/j.bmcl.2005.03.106 · Source: PubMed

    Abstract

    A novel series of non-nucleoside HCV NS5B polymerase inhibitors was prepared from a (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid template. Solution and solid phase analog synthesis focused on the northern region of the template combined with structure based design led to the discovery of several potent and orally bioavailable lead compounds.