Metabolic adaptation at birth

ArticleinSeminars in Fetal and Neonatal Medicine 10(4):341-50 · September 2005with43 Reads
Impact Factor: 3.03 · DOI: 10.1016/j.siny.2005.04.001 · Source: PubMed


    After birth, the neonate must make a transition from the assured continuous transplacental supply of glucose to a variable fat-based fuel economy. The normal infant born at term accomplishes this transition through a series of well-coordinated metabolic and hormonal adaptive changes. The patterns of adaptation in the preterm infant and the baby born after intrauterine growth restriction are, however, different to that of a full-term neonate, with the risk for former groups that there will be impaired counter-regulatory ketogenesis. There is much less precise linkage of neonatal insulin secretion to prevailing blood glucose concentrations. These patterns of metabolic adaptation are further influenced by feeding practices.