New pregnane glycosides from Caralluma dalzielii

ArticleinSteroids 70(9):573-85 · September 2005with17 Reads
Impact Factor: 2.64 · DOI: 10.1016/j.steroids.2005.03.013 · Source: PubMed

    Abstract

    Twenty-seven new pregnane glycosides were isolated from the whole plant of Caralluma dalzielii, and their structures elucidated from extensive 2D NMR analysis as well as ESI-MS experiments. All isolated compounds were tested for their antiproliferative activity on J774.A1, HEK-293, and WEHI-164 cell lines. Moderate to high potency of cytotoxicities were found in almost all tested compounds, confirming the significant cytotoxic activity of pregnane glycosides.