Exposure to bisphenol A is associated with recurrent miscarriage

Department of Obstetrics and Gynecology, Nagoya City University Medical School, Nagoya, Japan.
Human Reproduction (Impact Factor: 4.57). 09/2005; 20(8):2325-9. DOI: 10.1093/humrep/deh888
Source: PubMed


Little is known about the influence of high exposure to bisphenol A on recurrent miscarriage and immunoendocrine abnormalities.
Serum bisphenol A, antiphospholipid antibodies (aPLs), antinuclear antibodies (ANAs), natural killer cell (NK) activity, prolactin, progesterone, thyroid-stimulating hormone (TSH) and free T4 were examined in 45 patients with a history of three or more (3-11) consecutive first-trimester miscarriages and 32 healthy women with no history of live birth and infertility. Subsequent pregnancy outcome and embryonic karyotype of abortuses were examined prospectively.
The mean+/-SD values for bisphenol A in patients were 2.59+/-5.23 ng/ml, significantly higher than the 0.77+/-0.38 ng/ml found for control women (P=0.024). High exposure to bisphenol A was associated with the presence of ANAs but not hypothyroidism, hyperprolactinaemia, luteal phase defects, NK cell activity or aPLs. A high level of bisphenol A in itself did not predict subsequent miscarriage.
Exposure to bisphenol A is associated with recurrent miscarriage.

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Available from: Yasuhiko Ozaki, Jun 17, 2014
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    • "Unfortunately, BPA had adverse effects as an endocrine disruptor, and became a major concern (Omoike et al., 2013). Considerable data indicate that exposure of humans to BPA is associated with increased risk for cardiovascular disease, miscarriages, decreased birth weight at term, breast and prostate cancer, reproductive and sexual dysfunctions, altered immune system activity, metabolic problems and diabetes in adults, and cognitive and behavioral development in young children (Braun et al., 2009, 2011; Rees- Clayton et al., 2011; Lang et al., 2008; Li et al., 2009; Miao et al., 2011; Sugiura-Ogasawara et al., 2005). These findings are entirely consistent with parallel studies that demonstrate reproductive, metabolic and neuro-developmental problems in animals exposed to environmentally relevant levels of BPA (Salian et al., 2009; Wei et al., 2011; Wolstenholme et al., 2011). "
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    • "Indeed, elevated placental hCG levels have been linked to pregnancy complications, such as preterm birth [60], fetal growth restriction (FGR) [61], and preeclampsia [62]. Importantly , high placental concentrations of BPA are associated with preeclampsia [4], and elevated plasma levels of BPA in pregnant women are linked to recurrent miscarriages [5] as well as FGR [6]. Therefore, BPA-induced increases in placental hCG expression and secretion may contribute to the pathogenesis of these pregnancy complications. "
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