Mining the posterior cingulae: Segregation between memory and pain components

Technical University of Denmark, Lyngby, Capital Region, Denmark
NeuroImage (Impact Factor: 6.36). 10/2005; 27(3):520-32. DOI: 10.1016/j.neuroimage.2005.04.034
Source: PubMed


We present a general method for automatic meta-analyses in neuroscience and apply it on text data from published functional imaging studies to extract main functions associated with a brain area-the posterior cingulate cortex (PCC). Abstracts from PubMed are downloaded, words extracted and converted to a bag-of-words matrix representation. The combined data are analyzed with hierarchical non-negative matrix factorization. We find that the prominent themes in the PCC corpus are episodic memory retrieval and pain. We further characterize the distribution in PCC of the Talairach coordinates available in some of the articles. This shows a tendency to functional segregation between memory and pain components where memory activations are predominantly in the caudal part and pain in the rostral part of PCC.

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Available from: Finn Årup Nielsen, Mar 11, 2014
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    • "Our study using a whole brain analysis extended these results in the limited bedding model, showing that ELS compared to standard rearing elicits alteration in functional brain responses to CRD broadly across circuits involved in the regulation of pain and emotion as described below. ANOVA revealed a significant main effect of 'ELS' widely across regions implicated in pain processing (Bromm, 2004;BushnellFreund et al., 2010;Hanamori et al., 1998;Krushel and van der Kooy, 1988;Nielsen et al., 2005;Saper, 1982). These included the anterior-ventral cingulate, retrosplenial ('posterior cingulate'), prelimbic ('prefrontal'), somatosensory (primary, secondary ), and insular (anterior, posterior) cortices (Hanamori et al., 1998;Krushel and van der Kooy, 1988;Saper, 1982), as well as the sensory thalamus, amygdala, periaqueductal gray, locus coeruleus/ lateral parabrachial nucleus, and anterior-dorsal pretectal area (Fig. 2, column 3). "
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