Spontaneous resolution of hemophagocytic syndrome and disseminated intravascular coagulation associated with parvovirus B19 infection in a previously healthy child
Gazi University, Engüri, Ankara, TurkeyJapanese journal of infectious diseases (Impact Factor: 1.16). 07/2005; 58(3):149-51.
A 10-year-old male with a brain abscess developed pancytopenia, liver dysfunction, disseminated intravascular coagulation (DIC) and decrease of immunoglobulin A (IgA) level during postoperative antibiotic and anticonvulsant therapy. A bone marrow examination revealed hemophagocytosis. Real-time PCR revealed parvovirus B19 infection. The hemophagocytic syndrome resolved without specific treatment. To our knowledge, this is the first report of a spontaneous resolution of parvovirus B19-associated hemophagocytic syndrome and DIC.
Full-text previewDOI: · Available from: nih.go.jp
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.
- [Show abstract] [Hide abstract]
ABSTRACT: Haemophagocytic syndromes (HS) are the clinical manifestation of an increased macrophagic activity with haemophagocytosis. Pathophysiology is related to a deregulation of T-lymphocytes and excessive production of cytokines. The main clinicobiological features are fever, hepatosplenomegaly, adenopathies, skin rash, neurological features, cytopenias, hypertriglyceridaemia, hyperferritinaemia and coagulopathy. Diagnosis is based on examination of the bone marrow which shows benign histiocytes actively phagocytosing haemopoietic cells. Acquired HS are mostly associated with an underlying disease such as immunodeficiency, haematological neoplasias and autoimmune diseases. Infection-associated HS was originally described by Risdall in 1979, in viral disease. Since the initial description HS has also been documented in patients with bacterial, parasitic or fungal infections. Epstein-Barr virus (EBV) is the causative agent in most cases. In EBV-associated HS, which sometimes has a fatal course, unregulated T-cell reaction or uncontrolled B-cell proliferation may release cytokines. Management of HS consists of early diagnosis, careful screening for, and prompt treatment of, infections and detection and therapy of any underlying disease. Prognosis of infection-associated haemophagocytic syndrome (IAHS) is better than that in other types of secondary HS. Management of cytokine imbalance should be useful to improve the outcome and reduce the mortality rate in these cases.
Conference Paper: Survey of fraud detection techniques[Show abstract] [Hide abstract]
ABSTRACT: Due to the dramatic increase of fraud which results in loss of billions of dollars worldwide each year, several modern techniques in detecting fraud are continually developed and applied to many business fields. Fraud detection involves monitoring the behavior of populations of users in order to estimate, detect, or avoid undesirable behavior. Undesirable behavior is a broad term including delinquency, fraud, intrusion, and account defaulting. This paper presents a survey of current techniques used in credit card fraud detection, telecommunication fraud detection, and computer intrusion detection. The goal of this paper is to provide a comprehensive review of different techniques to detect frauds.
- [Show abstract] [Hide abstract]
ABSTRACT: Hemophagocytic syndrome is a systemic reactive histiocytic proliferative disorder affecting the reticuloendothelial system. Skin lesions develop in 12.5% to 55.6% of the patients. We report a 35-year-old woman with systemic lupus erythematosus and Graves' disease complicated with parvovirus B19-associated hemophagocytic syndrome. She presented with slightly infiltrated erythematous macules and plaques with ulcers on the scalp, face, and back. A skin biopsy specimen taken from an area of facial erythema demonstrated typical phagocytic cells in the skin. Hemophagocytic syndrome-associated specific cutaneous lesions should be included in the differential diagnosis of facial and nonfacial erythema in patients with systemic lupus erythematosus.