Article

Speech-language characteristics of children with Sotos syndrome

Munroe-Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha, Nebraska 68198-5450, USA.
American Journal of Medical Genetics Part A (Impact Factor: 2.16). 08/2005; 136A(4):363-7. DOI: 10.1002/ajmg.a.30799
Source: PubMed

ABSTRACT

The purpose of this research study was to evaluate the communication of individuals with Sotos syndrome in order to better characterize common speech and language patterns. Sixteen children with Sotos syndrome received an in-depth communication assessment using standardized procedures. Assessments of speech skills, language skills, voice, fluency, and social-pragmatic interactions were completed. Results of the evaluations indicated that individuals with Sotos syndrome are prone to: (a) language impairments (particularly expressive), (b) speech sound production impairments, (c) voice impairments, (d) dysfluencies (stuttering), and (e) average social-behavioral pragmatic interaction characteristics.

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    • "Studies investigating communication and language skills in Sotos syndrome indicate characteristic difficulties in speech articulation including delayed or no speech development (Compton et al, 2004; Morrow et al., 1990; Okamoto, 2010) and limited expressive language (Bale et al., 1985; Mauceri et al., 2000; Mourisden & Hansen, 2002). The most extensive cohort study by Ball et al. (2005) reported that individuals with Sotos syndrome showed greater impairments in expressive and receptive language compared to the normative sample. In contrast, two cohort studies (Finegan et al., 1994; Sarimski, 2003) found there to be no deficits in language. "
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    ABSTRACT: In this study we describe the levels of clinically significant behavior in participants with Sotos syndrome relative to three matched contrast groups in which the behavioral phenotype is well documented (Autism Spectrum Disorder, ASD; Prader-Willi, and Down syndromes). Parents and carers of 38 individuals with Sotos syndrome (mean age = 17.3; SD = 9.36), completed questionnaires regarding self-injury, aggression, repetitive behavior, autism spectrum phenomenology, overactivity, impulsivity and mood, interest and pleasure. Individuals with Sotos syndrome showed an increased risk of self-injurious behavior, physical aggression, and destruction of property relative to the Down syndrome group but not a greater risk of stereotyped behavior. Impulsivity and levels of activity were also significantly higher relative to those with Down syndrome and comparable to those with ASD. A large proportion of participants met the cut off score for ASD (70.3%) and Autism (32.4%) on the Social Communication Questionnaire. Social impairments were particularly prominent with repetitive behavior and communication impairments less characteristic of the syndrome. Interestingly, preference for routine and repetitive language were heightened in individuals with Sotos syndrome and the repetitive behavior profile was strikingly similar to that observed in individuals with Prader-Willi syndrome. These findings build upon previous research and provide further evidence of the behavioral phenotype associated with Sotos syndrome. © 2015 Wiley Periodicals, Inc.
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