Analysis of structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N '-[4-(methylsulfonylamino)benzyl]thiourea analogues as TRPV1 antagonists

ArticleinBioorganic & Medicinal Chemistry Letters 15(18):4136-42 · October 2005with27 Reads
Impact Factor: 2.42 · DOI: 10.1016/j.bmcl.2005.06.009 · Source: PubMed

    Abstract

    The structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues have been investigated as TRPV1 receptor antagonists. The 2-halogen analogues showed enhanced antagonism compared to the prototype antagonist.