DCD - A novel plant specific domain in proteins involved in development and programmed cell death

European Molecular Biology Laboratory, Heidelburg, Baden-Württemberg, Germany
BMC Bioinformatics (Impact Factor: 2.58). 02/2005; 6(1):169. DOI: 10.1186/1471-2105-6-169
Source: PubMed


Recognition of microbial pathogens by plants triggers the hypersensitive reaction, a common form of programmed cell death in plants. These dying cells generate signals that activate the plant immune system and alarm the neighboring cells as well as the whole plant to activate defense responses to limit the spread of the pathogen. The molecular mechanisms behind the hypersensitive reaction are largely unknown except for the recognition process of pathogens. We delineate the NRP-gene in soybean, which is specifically induced during this programmed cell death and contains a novel protein domain, which is commonly found in different plant proteins.
The sequence analysis of the protein, encoded by the NRP-gene from soybean, led to the identification of a novel domain, which we named DCD, because it is found in plant proteins involved in development and cell death. The domain is shared by several proteins in the Arabidopsis and the rice genomes, which otherwise show a different protein architecture. Biological studies indicate a role of these proteins in phytohormone response, embryo development and programmed cell by pathogens or ozone.
It is tempting to speculate, that the DCD domain mediates signaling in plant development and programmed cell death and could thus be used to identify interacting proteins to gain further molecular insights into these processes.

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    • "contrasting chromosome 7H sibling classes within each F 3 family . Table 2 Genes in the HvNax3 intervals of rice and Brachypodium Rice or Brachypodium ortholog a ( barley marker ) Homology / inferred function LOC_Os06g07770 ( HYI ) Contains DCD domain . DCD proteins are a plant - specific group of proteins and presently have no ascribed function ( Tenhaken et al . 2005 ) LOC_Os06g07780 R - SNARE . Facilitate membrane fusion . Most similar to the three R - VAMP71 subfamily members of Arabidopsis ( http : / / www . tc . umn . edu / ~sande099 / atsnare . htm ) , which mediate vesicle fusion with the tonoplast ( Uemura et al . 2004 ; Carter et al . 2004 ) . Vesicle trafficking LOC_Os06g07800 Hypothetical "
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