Effect of quercetin supplementation on lung antioxidants after experimental influenza virus infection

Department of Respiratory Virology, VP Chest Institute, University of Delhi, Delhi 110-007, India.
Experimental Lung Research (Impact Factor: 1.41). 07/2005; 31(5):449-59. DOI: 10.1080/019021490927088
Source: PubMed


In the mice, instillation of influenza virus A/Udorn/317/72(H3N2) intranasally resulted in a significant decrease in the pulmonary concentrations of catalase, reduced glutathione, and superoxide dismutase. There was a decrease in vitamin E level also. These effects were observed on the 5th day after viral instillation. Oral supplementation with quercetin simultaneous with viral instillation produced significant increases in the pulmonary concentrations of catalase, reduced glutathione, and superoxide dismutase. However, quercetin did not reverse the fall in vitamin E level associated with the viral infection. It is concluded that during influenza virus infection, there is "oxidative stress." Because quercetin restored the concentrations of many antioxidants, it is proposed that it may be useful as a drug in protecting the lung from the deleterious effects of oxygen derived free radicals released during influenza virus infection.

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Available from: Pankaj Kumar, Sep 02, 2014
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    • "High mannose-binding lectins (HMBL) are powerful influenza and HIV inhibitors [154]. Rutin, quercetin, and related compounds, extracted from elderberry fruit (Sambucus nigra L.) [155] [156] [157] [158] [159] [160] [161] are other HA inhibitors. Xylopine and rosmaricin have an amine group that interacts with HA [162] [163]. "
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    • "Docking studies have been performed using MOE 2008 . 10 . The crystal structure of HN protein ( PDB ID : 1USX ) was retrieved from Protein Data Bank ( http : / / www . rcsb . org / pdb / home / home . do ) ( Kumar et al . , 2005"
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