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The effects of prenatal maternal stress on children's cognitive development: Project Ice Storm

  • Lady Davis Institute - Jewish General Hospital

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There exists considerable research on the effects of prenatal maternal stress on offspring. Animal studies, using random assignment to experimental and control groups, demonstrate the noxious effects of prenatal maternal stress on physical, behavioural and cognitive development. The generalizability of these results to humans is problematic given that cognitive attributions moderate reactions to stressors. In humans, researchers have relied upon maternal anxiety or exposure to life events as proxies for the stressors used with animals. Yet, the associations between maternal anxiety or potentially non-independent life events and problems in infants are confounded by genetic transmission of temperament from mother to child. We summarize the literature on prenatal maternal stress and infant cognitive development, leading to the conclusion that the human literature lacks the ability to separate the effects of the objective exposure to a stressor and the mother's subjective reaction. We then describe our prospective Project Ice Storm in which we are following 150 children who were exposed in utero to a natural disaster. We demonstrate significant effects of the objective severity of exposure on cognitive and language development at age two years with important moderating effects of the timing during pregnancy. The implications of our findings are discussed.
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The effects of prenatal maternal stress on children’s cognitive
development: Project Ice Storm
Department of Psychiatry, McGill University, Que
bec, Canada, and
Douglas Hospital Research Centre, Verdun, Que
There exists considerable research on the effects of prenatal maternal stress on offspring. Animal studies, using random
assignment to experimental and control groups, demonstrate the noxious effects of prenatal maternal stress on physical,
behavioural and cognitive development. The generalizability of these results to humans is problematic given that cognitive
attributions moderate reactions to stressors. In humans, researchers have relied upon maternal anxiety or exposure to life
events as proxies for the stressors used with animals. Yet, the associations between maternal anxiety or potentially non-
independent life events and problems in infants are confounded by genetic transmission of temperament from mother to child.
We summarize the literature on prenatal maternal stress and infant cognitive development, leading to the conclusion that the
human literature lacks the ability to separate the effects of the objective exposure to a stressor and the mother’s subjective
reaction. We then describe our prospective Project Ice Storm in which we are following 150 children who were exposed in utero
to a natural disaster. We demonstrate significant effects of the objective severity of exposure on cognitive and language
development at age two years with important moderating effects of the timing during pregnancy. The implications of our
findings are discussed.
Keywords: Cortisol, foetal programming hypothesis, human, hypothalamopituitary adrenal axis, language development,
longitudinal study
Retrospective studies on humans, and experimental
research with animals, suggest that psychosocial
stressors during pregnancy can influence the physical,
behavioural and cognitive outcomes of the offspring.
There are important gaps in the existing literature,
Research on prenatal maternal stress is hampered
by methodological constraints. Although animal
studies are ideal in their control of prenatal and
postnatal environments, the application of findings to
humans is not always clear. Human studies, on the
other hand, do not allow for stressful events to be
randomly assigned during pregnancy by an experi-
menter and may be compromised by a host of
potential confounds.
Natural and man-made disasters act as “natural
experiments”, randomising the distribution of stress
exposure. The Que
bec Ice Storm of January 1998
qualifies as such an event. The storm resulted in
electrical power failures for more than three million
individuals for anywhere from 6 h to more than
5 weeks. As such, large numbers of pregnant women
in various stages of pregnancy were randomly
exposed to varying degrees of storm-related
The purpose of this paper is to review the existing
literature on the effects of prenatal maternal stress,
particularly with respect to infant cognitive develop-
ment, and to present an introduction to our on-going
longitudinal study of children exposed to the January
1998 Quebec Ice Storm while in utero. In addition, we
will present early findings with respect to effects of
ISSN 1025-3890 print/ISSN 1607-8888 online q 2005 Taylor & Francis Group Ltd
DOI: 10.1080/10253890500108391
Correspondence: S. King, Douglas Hospital Research Centre, 6875 LaSalle Blvd., Verdun, Quebec H4H 1R3, Canada. Tel: 1 514 761 6131.
Ext. 2353. Fax: 1 514 762 3049. E-mail:
Stress, March 2005; 8(1): 35–45
the ice storm stress on children’s cognitive and
language development at age 2 years.
Effects of prenatal maternal stress (PNMS)
on foetal and child development
There is a sizeable literature on the effects of prenatal
maternal stress (PNMS) in rodents, non-human
primates, and in humans. In humans, studies of
prenatal maternal anxiety (Crandon 1979a, 1979b,
Field et al. 1985, Grimm 1961) and of prenatal
exposure to severe life events (Lou 1993) suggest that
one of the first effects is on perinatal outcomes, with
PNMS associated with a variety of severe obstetric
complications, but especially with preterm birth
(Paarlberg et al. 1999, 1995).
Weinstock reviewed the literature on prenatal stress,
particularly rodent studies, and reports wide-ranging
effects (Weinstock 2001). Rodent studies typically use
various forms and intensities of restraint or noise to
stress pregnant dams one to three times per day,
usually for several days at some point between days 10
and 22 of gestation. Behavioural effects of prenatal
exposure to various forms of stress are seen in social
deficits and behaviours in rodent offspring suggestive
of internalizing problems such as anxiety and
depression. Controlled studies with non-human
primates also indicate that PNMS results in beha-
vioural alterations suggestive of internalizing problems
(Clarke and Schneider 1993, Schneider 1992b).
Naturalistic studies with humans find similar effects
on behaviour (Huizink et al. 2004). Studies of prenatal
maternal anxiety (O’Connor et al. 2002, Van den
Bergh and Marcoen, 2004), prenatal exposure to
stressful life events (Stott 1973), and even prenatal
exposure to dexamethasone (a synthetic glucocorti-
coid) (Trautman et al. 1995) are associated with
children who are more withdrawn, anxious and
depressed. A handful of retrospective studies have
examined associations between independent stressors
and mental health outcomes. A classic study by
Huttunen and Niskanen (1978) examined rates of
mental illness in samples from Finland in which the
father had died either while the person was in utero or
during the person’s first year of life. Significantly
greater rates of schizophrenia and other mental illness
were found in the prenatal stress exposure group. Van
Os and Selton (1998) also found a significant increase
in rates of schizophrenia in Holland as a function of
the German invasion during World War II. These
studies show a specific effect of the timing of the
stressor during the pregnancy, with the most noxious
effects associated with exposure during the second
A number of other studies in non-human primates
suggest that social stressors during gestation have
negative effects on neurological functioning in the
offspring, including reduced motor activity and
maturity, less muscle tone and co-ordination, slower
reaction time, and poorer balance (Schneider and Coe
1993, Schneider et al. 1999). In humans, significantly
lower Prechtl neurological inventory scores 414 days
after birth were found when mothers had experienced
severe life events by mid-pregnancy (Lou et al. 1994).
PNMS studies have also discovered cognitive
sequelae. In rodents, PNMS has resulted in impair-
ment in maze learning (Nishio et al. 2001), reversal of
learning set (Weller et al. 1988), and short and long-
term memory (Gue 2004), while some studies show
no effect on, for example, acquisition, discrimination
or extinction in an operant conditioning task (Weller
et al. 1988) or on object memory (Bowman 2004).
Studies of non-human primates have found that both
chronic stress during pregnancy (Schneider and Coe
1993, Schneider et al. 1999) and two-weeks of
adrenocorticotrophic hormone administration at
mid-gestation (Schneider 1992a) predict poorer
attention, greater distractibility, and delayed object
permanence (Schneider 1992a), an early indicator of
cognitive development. Similar findings have been
made in humans when linking mothers’ self-reported
stress levels (McIntosh et al. 1995) or anxiety
(Van den Bergh and Marcoen 2004) during pregnancy
to risk of attention-deficit and hyperactivity disorder
(ADHD) in children. In a longitudinal study of
anxiety in pregnant mothers and outcomes in their
babies in England, O’Connor et al. showed that, even
after controlling for a host of potential confounding
factors, higher levels of anxiety experienced by the
mother at weeks 1222 of pregnancy significantly
predicted more severe attention problems in the
children at 18 and 32 months of age (O’Connor et al.
2002). Another study found that at 9 years of age,
children of women who were highly anxious during
pregnancy showed more attention deficits than
children of low anxiety women (Mulder et al. 2002).
Chronic stress resulting from moderate daily hassles
(Stott 1973) and state and/or trait anxiety (Brouwers
et al. 2001) are also associated with delayed language
development and lowered intellectual functioning,
The effects of PNMS on cognitive development
may be due to an effect on foetal brain development.
PNMS in rodents predicts the degeneration of
hippocampal neurons (Uno et al. 1989, 1990) and
reductions in the size of the hippocampus by as much
as 30% (Uno et al. 1994), which might be manifest in
reduced memory functioning. Lower scores on
cognitive tests may be due, in part, to the indirect
effects of prenatal stress on attentional functioning.
Timing of teratogens
It has been hypothesised that it may be less the type of
disruption of foetal neural development than the
timing that is critical in determining risk for negative
S. King & D. P. Laplante36
outcomes since the timing of an insult may indicate
which developmental processes are likely to be
affected (Mednick et al. 1988). A common theme
among many studies of PNMS is that the worst
outcomes are associated with stressors timed at mid-
gestation (Glynn et al. 2001, Huizink et al. 2004,
Huttenen and Niskanen 1978, O’Connor et al. 2002,
2003, Schneider et al. 1992, Watson et al. 1999),
a critical period for brain development (Andreason
1999, Weinberger 1995). Moreover, if outcomes are
mediated through foetal hypothalamus pituitary
adrenal (HPA) axis activity, its influence should only
be seen in mid-gestation after the foetal HPA axis
becomes functional (Gitau et al. 2001). Furthermore,
reports suggest that mothers may become more
immune to the potential negative effects of stress as
their pregnancy advances into the 3rd trimester of
pregnancy (Glynn et al. 2001, Kammerer et al. 2002).
However, some researchers have found effects of 3rd
trimester stress on obstetric complications (Crandon
1979b). Also, it has been reported that early gestation
stress in non-human primates has a more detrimental
effect on birth weight and neuromotor functioning
than mid-late gestational stress (Schneider et al.
1999). Thus, the question of timing of prenatal stress
is intimately associated with the outcome factor of
Critique of the literature
There is no shortage of studies of prenatal maternal
stress. Yet, to date, there have been no ideal studies of
PNMS that can determine the extent, longevity and
mechanisms of the effects in humans. In animal
research, “subjects” can be randomly assigned to
various stress conditions. While these studies can
provide working hypotheses on the mechanisms by
which PNMS influences outcomes, there are limi-
tations to animal studies. First, rats are not born at the
same stage of development as humans are. Secondly,
rat and primate studies are unable to take into account
the kinds of cognitive appraisals that occur in humans
between an external stressor and the response to the
stressor which may well be the critical variable in
determining a pregnant woman’s physiological
response to a stressor (Lazarus 1991) and subsequent
damage to the foetus.
The human studies that do assess “stress” during
the pregnancy are also unable to tease apart the
various aspects of the process. Studies of anxiety
during pregnancy cannot separate state versus trait
anxiety, the latter of which may be passed on to babies,
in part, genetically (Rowe 1994) and through
parenting style and modelling, as well as through the
complicated mechanisms of gene-by-environment
correlations (Rutter and Silberg 2002). Studies of
life events during pregnancy are equally hampered in
that such events are far from being randomly assigned
to women; divorce and job loss are not always
“independent” life events but may, instead, be
influenced by heritable personality traits. Most
human studies of stress also have limited statistical
power: An extremely large sample of pregnant women
is required to include a sufficient number who had
experienced an independent life event. And the large-
scale retrospective studies of independent life events
(death of father, hurricane, tornado, foreign invasion)
are too far removed from the incident to assess the
pregnant woman’s appraisal of the event. What is
needed to permit us to tease apart the objective and
the subjective components of the stress process is a
man-made or natural disaster that affects large
numbers of pregnant women in a quasi-random
Disaster research
Disasters provide unique opportunities to study the
effects of stress in people. Disasters are characterised
by “disruption exceeding the adjustment capacity of
the affected community” (Lechat 1979, p. 11) and
range from oil spills to hurricanes and earthquakes.
Important dimensions of disasters include loss
(of persons or property), threat to life or physical
integrity, scope and duration, blame for the event
(man versus nature), familiarity with similar events,
speed of onset and amount of displacement or change.
Since events differ along many dimensions, one must
tailor-make disaster questionnaires in order to assess
degree of exposure.
Standardised instruments, however, have proven
useful in estimating the psychological impact of
disasters. One review of 52 studies concluded that, on
average, sudden onset disasters are associated with a
17% increase in the prevalence of psychological
disorders (Rubonis and Bickman 1991) including
post-traumatic stress disorder (Palinkas et al. 1993).
When response is measured along a psychopathology
continuum, disasters have been shown to be associated
with significant increases in psychological symptoms.
One review uncovered 7 so-called “natural exper-
iments” in which a disaster struck a community that
had recently been surveyed in an epidemiological
study, providing estimates of pre- and post-disaster
symptoms on the same subjects. These studies confirm
the disaster effect (Bromet and Dew 1995). In some
instances, the emotional effects of a disaster may last
for many years as shown in a recent 11-year follow-up
of women evacuated to Kyev following the Chernobyl
nuclear power plant explosion (Adams et al. 2002).
Questions remaining about prenatal maternal stress
The available literature on prenatal maternal stress
suggests that a large gap exists: Understanding how
the various elements of the stress process
Effects of prenatal maternal stress 37
(in particular, the objective exposure versus the
subjective reaction) operate, individually and in
combination, to influence cognitive and other out-
comes in the unborn human child. In order to
successfully disentangle the objective elements of the
stress process from the mother’s own temperament
(which can be passed on to her children through a
combination of genetics, the prenatal environment,
and parenting style, not to mention the influence of
the mother’s own temperament on her response style
as she completes questionnaires rating her child) one
requires an independent stressor that affects large
numbers of pregnant women and which is distributed
in a relatively random fashion.
Project Ice Storm
Project Ice Storm was initiated soon after a series of
freezing rain storms hit Southern Quebec in Canada
between January 5 and 9, 1998. The build-up of ice on
utility lines toppled more than 1000 electrical pylons
and more than 25,000 wooden transmission poles
resulting in electrical power failures during the dead of
winter for more than 1.4 million households in more
than 700 municipalities. More than three million
individuals experienced power outages ranging from a
few hours to more than 6 weeks. Four hundred and fifty
emergency shelters were established which slept as
many as 17,000 people in a single night. In Quebec, at
least 27 people died as a result of hypothermia,
accidents, or carbon monoxide poisoning or fire
associated with unconventional heating methods.
Thousands of people were injured or hospitalized as a
result of the storm. The agricultural sector suffered
major financial losses associated with the power outage:
Thousands of animals were lost when ventilation and
heating systems or milking machinery could not be
kept going. The maple syrup industry was nearly
obliterated due to the near total loss of branches on
maple trees. There were $1 Billion worth of insurance
claims, $3 Billion of lost income to businesses and $1
Billion dollars required to repair hydroelectric infra-
structure. More than 46,000 people were laid off work
as a direct or indirect consequence of the crisis.
Everyone had to deal with 5-inch ice build-up on cars,
streets, trees and roofs. Several buildings collapsed
under the weight of ice and snow and more than 200
people were hospitalized with severe injuries as a result
of falling off their roofs while removing snow and ice; 3
people died in this way. (Statistics provided by Ministe
de la Se
Thus, the 1998 Quebec ice storm provided a unique
opportunity. The objective of Project Ice Storm is to
determine the nature and duration of the effects of an
independent stressor during pregnancy on the unborn
child in a prospective design with a relatively
large sample of families. By conducting repeated
assessments of women affected by the ice storm, as
well of their children, over several years, we are
determining the effects of objective stress exposure
and subjective stress reaction on perinatal outcomes,
maternal postpartum depression, and the behavioural,
physical and cognitive development of the children.
Sample development
The area of Que
bec that was worst hit by the storm
was the region called the Monte
gie, an area
southeast of Montreal that is mainly suburban and
rural and which came to be known as “the Black
Triangle”. To identify potential subjects, we contacted
the four hospitals in the region and obtained the
names of physicians authorized to deliver babies there.
Approximately 20 doctors identified more than 1400
women who met our inclusion criteria: They were
pregnant on January 9, 1998 or became pregnant
during the 3 months following the storm, were 18
years of age or older, and spoke fluent French.
On June 1, 1998, we delivered the appropriate
number of pre-stamped questionnaires to each
participating clinic where clinic staff addressed the
envelopes and mailed them. Of the 1440 question-
naires sent out, 224 were returned for a response rate
of 15.5% which is considered to be the norm for
unsolicited postal questionnaires. This response rate
may be explained also by the fact that during the
summer of 1998 the potential subjects were either
pregnant or caring for a newborn, as well as for any
older children, and may also have been dealing with
ice storm-related damage to the home and financial
sequelae. Of the 224 women who responded to the
first questionnaire, 178 provided their name and
address and agreed to further contact. We have
continued to follow as many of these families as
possible; many have not been followed since because
their ice storm pregnancy ended in miscarriage or
stillbirth, while others have been lost to follow-up, and
a small number have refused continued involvement,
leaving 141 families who are continuing their
participation in the study.
In total, we have made contact with the families 7
times between June 1998 and the children’s 6th
birthday with an eighth contact on-going and a ninth
in the planning stage for an evaluation at age 7
Questionnaire #1—Reactions to the Storm, was sent
on June 1, 1998. The primary goal of the first
questionnaire was to evaluate the extent of the
women’s objective exposure to the ice storm, as well
as their subjective reaction to the storm. In order to
assess objective exposure, we examined the literature
on natural disasters. We formulated questions (Table I)
S. King & D. P. Laplante38
that would reflect the participant’s experiences related
to 4 categories of exposure used in other disaster
studies: Threat, Loss, Scope and Change (Bromet and
Dew 1995). Each dimension was scored on a scale of
08, ranging from no exposure to high exposure.
A total objective stress score was calculated by
summing scores from all four dimensions using
McFarlane’s approach (McFarlane 1988). Because
there was no theoretical basis to believe that any one of
the four dimensions of our scale was more distressing
than the other dimensions, and based on McFarlane’s
study of Australian fire fighters (McFarlane 1988),
each dimension was weighted equally to obtain the
total score of our scale which we dubbed STORM32.
Questionnaire #1 also included an assessment of the
women’s subjective stress reaction to the ice storm. In
the literature on natural disasters and trauma, one
instrument stands out as being the gold-standard
measurement of subjective reactions: The Impact of
Event Scale Revised (Weiss and Marmar 1997). The
22-item scale describes symptoms from three cat-
egories relevant to post-traumatic stress disorder:
Intrusive thoughts, hyperarousal and avoidance.
A French-version of the scale was developed and
validated by our team (Brunet et al. 2003) to reflect the
mothers’ symptoms relative to the ice storm crisis.
Participants respond on a 5-point Likert scale, from
Not at all to Extremely, the extent to which the behaviour
describes how they felt over the preceding seven days.
To assess the severity of maternal psychiatric and
stress-related symptoms in general, we have used, at
various times, either the General Health Question-
naire (Goldberg 1972) which includes scales reflec-
ting anxiety, depression, somatic symptoms and
dysfunction, or the Edinburgh Postnatal Depression
Scale (Cox et al. 1987). Mothers have also indicated,
since the birth of their baby, their experiences with
any other life events in the preceding 12 months using
a modified version of the Life Experiences Survey
(Sarason et al. 1978). We have also assessed the
mothers’ personality using the short form (60-item)
NEO Five Factor Inventory (Costa and McCrae
1992) which includes scales for neuroticism, extro-
version, openness to experience, agreeableness and
conscientiousness. Using data on maternal and
paternal education and occupation, we estimated
socioeconomic status using the Hollingshead scale
(Hollingshead 1973).
Laboratory assessment. When the children were 2 years
old, a subset of 61 families participated in a laboratory
assessment of cognitive (Bayley Scales of Infant
Development, 2nd Edition Bayley 1993), language
(MacArthur Communicative Development Inventory
(Fenson et al. 1993)) and functional play (Zelazo and
Kearsley 1980) development. These families were
selected to represent the lowest and highest thirds in
severity of objective ice storm stress, and the 3
trimesters of exposure. Children with severe low birth
weight, Caesarian-section delivery, or prenatal
smoking or other severe prenatal stressor (e.g. death
of close relative) were excluded.
Results: The ice storm and cognitive
Here, we provide an overview of findings on the effects
of prenatal exposure to the ice storm on cognitive
development at age two years. These results have been
Table I. Questions used to assess the four dimensions (Threat, Loss, Scope, and Change) of our objective stress questionnaire that the
mothers completed shortly after the ice storm.
Threat Loss Scope Change
1. Were you injured? 1. Did your residence suffer
damage as a result
of the ice storm?
1. How many days were
you without electricity?
1. Did your family stay
together for the duration
of the ice storm?
2. Was anyone close to
you injured?
2. Did you experience a
loss of personal income?
2. How many days were
you without the use
of your telephone?
2. Did you spend any
time in a temporary
3. Were you ever in
danger due to:
3. Did you suffer a
loss of business income?
3. How often were you
required to change residence
during the ice storm?
3.1. ...the cold 4. Did you take in
guests during the ice
3.2. ...exposure to downed electrical
power lines
5. Did you experience an
increase in physical work
during the ice storm?
3.3. ...exposure to carbon monoxide
3.4. ...lack of potable water
3.5. ...lack of food
3.6. ...falling branches & ice
Effects of prenatal maternal stress 39
published (Laplante et al. 2004), or are under review
(Laplante et al. submitted), elsewhere.
Reaction to the storm
The mothers in our sample spent, on average, 14.9
ðSD ¼ 8:9Þ days without electricity and 4.4 ðSD ¼
8:4Þ days without the use of their telephone.
Approximately 65% of the mothers spent at least
one night away from their home for a period, on
average, of 9.2 ðSD ¼ 11:2Þ nights away from their
home, changing locations, on average, 1.3 ðSD ¼ 1:2Þ
times. Of the mothers who remained in their homes
during the ice storm, 37.7% had guests staying with
them: On average, 1.4 ðSD ¼ 2:4Þ guests stayed for an
average of 30 days ðSD ¼ 5:9Þ: Approximately half of
the mothers reported damage to their homes (46.6%)
and loss of personal income (44.7%) directly related
to the ice storm. Six percent of the mothers were
physically injured as a result of the ice storm and
37.7% reported being worried about the personal
safety of loved ones.
Based on the items included in the four 8-point
scales of our STORM32 objective stress measure, the
mothers in our sample scored, on average, 3.0 points
ðSD ¼ 2:6Þ on our Scope dimension, 3.0 points ðSD ¼
1:9Þ on our Loss dimension, 3.1 points ðSD ¼ 1:7Þ on
our Change dimension, and 1.5 points ðSD ¼ 1:4Þ on
our Threat dimension. Overall, the mothers in our
sample scored, on average, 10.4 points ðSD ¼ 4:9Þ on
our total STORM32 scale.
In terms of subjective stress reaction, the mothers in
our sample scored, on average, 11.9 points ðSD ¼
12:5Þ on our French-version of the IES-R scale. Using
the cut-off of 22 points on this scale, 16.6% of the
mothers exhibited levels of subjective stress reaction
that placed them within the clinical range for potential
post-traumatic stress disorder.
Intellectual, language and play abilities at 2 years
To examine interactions between trimester of
exposure and severity of ice storm stress, we split
STORM32 into three groups (low, moderate and high
stress), and contrasted the low stress group with the
combined moderate-high stress group. We found that
moderate-high objective prenatal maternal stress was
associated with poorer intellectual and language
functioning at the age of two years (Laplante et al.
2004). These findings were reinforced by the results of
our analyses of the children’s play behaviours
(Laplante et al. submitted). For intellectual abilities,
children whose mothers were exposed to the ice storm
during their 1st or 2nd trimester of pregnancy and
who experienced moderate or high objective stress had
significantly lower Bayley MDI scores. For the 1st
trimester exposed children, the moderate-high stress
group had an average score 14 points lower (i.e. 0.95
of 1 SD) than their counterparts in the low stress
group (see Figure 1). For the 2nd trimester exposed
group, children from the moderate-high stress group
scored an average of 19.5 points lower than their
counterparts in the low stress group, a 1.3 SD
difference. These effects remained even after control-
ling for age at testing, birth weight, subjective stress
scores (IES-R), and socioeconomic status, with an
adjusted overall difference of 9.5 points between stress
groups across all three trimesters. There were no
effects of stress severity on the MDI scores for children
exposed in the third trimester of pregnancy.
Using maternal reports of their children’s word
comprehension and word use at age 2 years, we found
Figure 1. Toddlers’ mean (^ standard error) Bayley mental development idex (MDI) scores at 2 years of age, as a function of objective
prenatal maternal stress levels (low, high) and trimester of exposure (1st, 2nd, or 3rd).
S. King & D. P. Laplante40
similar effects of objective stress severity, but without
the differential effect of trimester of exposure
(Figure 2). Children whose mothers were exposed to
moderate-high objective stress spoke, on average, 20.2
fewer words ðp , 0:001Þ which represents a 30%
reduction in productive vocabulary. There was also a
significant effect of objective ice storm exposure on
receptive vocabulary, again with no differential effect
by timing of exposure. At age 2 years, children of
mothers from the moderate-high objective stress
group understood, but did not yet speak, an average
of 10.5 fewer words ðp , 0:001Þ than their low stress
counterparts, representing 11% fewer words.
Because a two year-old’s performance on structured
tasks may reflect temperamental or behavioural
characteristics rather than purely cognitive skills, we
included a non-structured free-play task that was
videotaped and rated blind to prenatal stress level. Toy
play during early childhood evolves in a predictable
manner and provides excellent discriminative and
predictive validity as a measure of cognitive function.
The youngest toddlers will engage in “stereotypical”
play which involves banging, waving or mouthing toys.
Older toddlers will engage in “relational” play by
touching two toys together in a non-functional
manner. A more mature level of toy play involves
using objects according to their intended function.
Thus, in “functional” toy play, a child may roll a car on
the floor while making car noises, or pour imaginary
tea from a pot into a teacup. The results of this study
support the findings from the Bayley Scales with
moderate-high stress children engaging in significantly
more stereotypical play and less functional play than
their low stress counterparts, and with the effects
limited to children exposed during the 1st and 2nd
trimesters (p , 0:01; Figure 3). For 2nd trimester
children, the level of objective maternal stress
(STORM32 score) accounted for 53.8% of the
variance in the level of the children’s functional toy
play, while the mother’s subjective stress (IES-R)
explained an additional 13.6% of the variance, even
after controlling for the children’s birth weights, the
number of obstetric complications experienced by the
mothers and the mothers’ level of anxiety during
pregnancy ðp , 0:005Þ: Maternal objective and sub-
jective PNMS was not related to the functional play
levels of children exposed during the 1st or 3rd
trimester of pregnancy.
We have conducted additional cognitive assess-
ments of the children at age 5
years. Preliminary
examination of the data suggests that the effects of
objective prenatal maternal stress on cognitive and
language development persist into middle childhood
(unpublished data). A repeat assessment is planned
for age 7
during 2005 2006.
The findings from Project Ice Storm strongly suggest that
a major stressful event, independent of maternal
personality factors, can have a negative impact on
cognitive and language development of the unborn
child. Other results not reported here also demonstrate
significant noxious effects of the severity and/or timing
of prenatal maternal stress on perinatal outcomes,
infant temperament, behavioural and emotional
functioning, and even physical development of
children exposed in utero. We have uncovered several
effects that are related to the timing of the stressor,
with a particular emphasis on the 2nd trimester.
Figure 2. Toddlers’ mean (^ standard error) MacArthur communicative development index (MCDI) scores for productive and receptive
language abilities at 2 years of age, as a function objective prenatal maternal stress levels (low, high) and trimester of exposure (1st, 2nd, or 3rd).
Effects of prenatal maternal stress 41
Furthermore, while there have been a handful of results
implicating the mother’s subjective reaction to the
stressor, the majority of findings implicate the degree of
her objective exposure to the event.
The mechanism by which prenatal maternal stress
affects the pregnancy and the subsequent develop-
ment of the children, however, remains unknown for
human populations, although maternal glucocorti-
coids are often cited as a likely teratogen. There is
much support for the role of maternal glucocorticoids
in the PNMS effect in animals (Weinstock 2001,
Schneider et al. 1992). In humans, indirect evidence
for effects of maternal hormones is available.
Trautman et al. (1995) conducted a study of children
whose mothers had received dexamethasone (DEX)
(a synthetic glucocorticoid) during pregnancy for
congenital adrenal hyperplasia (CAH). They found
that these children were significantly more withdrawn
and emotional and significantly less social at one year
of age, and had significantly higher scores on a scale of
internalising problems at ages 23 years than a group
of comparison children whose CAH mothers went
untreated with DEX. These data suggest that it is
maternal stress hormones that are responsible for the
effects seen in children.
Although we have shown, in Project Ice Storm, that
objective PNMS in early gestation predicts poorer
cognitive functioning, we have not so far been able to
show that these findings are the direct effects of the
stress exposure either on maternal cortisol levels or on
disruptions in foetal brain development. Although we
obtained salivary cortisol samples from the mothers in
our study at the time of our first contact, those samples
were taken five-to-six months after the storm, when
half of the mothers had given birth, rendering our
maternal cortisol data difficult to interpret.
There are also animal studies showing that PNMS is
associated with alterations in stress reactivity in the
offspring which may be involved in a variety of
cognitive and behavioural outcomes. In rhesus
monkeys, for example, prenatal exposure to either
glucocorticoids or to stress is associated with greater
increases in cortisol following a stressor (Uno et al.
1994). These offspring also show a slower recovery
following stress (Uno et al. 1994). Greater stress
reactivity is also found in prenatally stressed rats
(Koehl et al. 1999, Takahashi and Kalin 1991,
Weinstock et al. 1992), whose stress-induced cortico-
sterone secretion is also prolonged, that is, their
recovery from the stressor is slower (Fride et al. 1986,
Maccari et al. 1995). We are currently analyzing data
related to the children’s hormonal stress responsivity
which may support an effect of PNMS on the
development of the foetal HPA axis. A subset of
children provided saliva samples before and after their
pre-kindergarten inoculation session. Their cortisol
data will be analyzed to determine effects of PNMS,
and to determine moderating effects of the trimester of
exposure and the child’s sex.
There are other potential mechanisms for the effect
of PNMS that Project Ice Storm is unable to investigate.
Although a stress- or disaster-related reduction in
supply of nutrients to the mother and foetus may be
involved in the process, we failed to include questions
about eating patterns in our initial ice storm
questionnaire. Maternal thyroid function may have
compromised as a result of the cold, but this, too, went
unmeasured. There was a great deal of water damage
to homes as a result of ice build-up on roofs which
fostered the production of moulds in many homes and
could, potentially, have had an effect on the pregnant
women. Yet this type of damage, as well, was not
Figure 3. Percentage of functional and stereotypical play exhibited by the toddlers as a function of level of maternal objective stress
(high or low) and trimester of exposure.
S. King & D. P. Laplante42
addressed in our survey. Finally, a compromised gas
exchange across the placenta may have been involved
in the stress effect seen in our sample, but these data
are not available in the majority of hospital records.
For a random subsample of cases, however, placental
weight at birth is available from hospital charts, and
we are currently investigating associations between
stress levels and placental weight on one hand, and
between placental weight and developmental out-
comes on the other.
Although we are lacking data on the immediate
biological processes that may have mediated between
stress exposure or stress reaction in the mother and
developmental processes in the foetus, we are in a
position to determine whether the effects of PNMS
exposure on cognitive outcomes are due to perma-
nent insults to brain development by obtaining
structural magnetic-resonance images (MRI) of the
children, a project currently in development.
Research suggests that either stress or administration
of stress hormones to pregnant females results in
severe degenerative changes in neurons within the
hippocampus (Uno et al. 1990), resulting in an
overall reduction in hippocampal volume, even
though the total brain volume remains unchanged
(Uno et al. 1994) in these animals. In addition,
magnetic resonance imaging studies indicate that this
hippocampal volume loss is maintained 2-years
postnatally (Uno et al. 1994). Using an acoustic
startle protocol with rhesus monkeys, Coe and
colleagues (Coe et al. 2003, Coe et al. 2002) report
similar findings to those obtained by Uno. Both early
(days 50 92) and late (days 105 147) stress to
pregnant non-human primate females result in a
reduction in the size (Coe et al. 2003) and alterations
to the shape (Coe et al. 2002) of the hippocampus.
To date, no study has used a prospective design to
examine the potential impact of prenatal maternal
stress on the structural development of the hippo-
campus in humans. Thus, our MRI scans of ice storm
children will target hippocampal volumes as well as
other regions.
Weather researchers agree that the visible effects of
global warming will be more frequent and more severe
extreme weather events. Moreover, man-made
threats, such as terrorist attacks on civilian popu-
lations, are becoming more prevalent. Such events will
lead to greater numbers of pregnant women facing
stressful events that are outside of their control and
that will result in foetuses experiencing increasing
levels of prenatal maternal stress. Therefore, research
is required to better understand the process by which
prenatal maternal stress influences prenatal develop-
ment and postnatal outcomes.
We propose that a first step in understanding these
mechanisms is to separate the stressful event into its
components, such as objective levels of exposure to
hardship, and subjective emotional reactions to that
hardship. Evaluation of objective stress involves
examining the specific events faced by the pregnant
women during the crisis, such as duration of power
loss, loss of income and amount of change to the
physical environment. The second component, sub-
jective reaction to the objective stress, involves
assessing the pregnant women’s psychological
response to these specific events. Borrowing from the
literature on post-traumatic stress disorder, these
subjective responses will include varying degrees of
hyperarousal, avoidance of the traumatic event, and
intrusive thoughts about the event. Separation of the
objective and subjective aspects of a person’s stressful
researchers to make recommendations on how to
prevent, or limit, the potential negative effects of
prenatal stress on the developing foetus. For example,
if it is found that particular aspects of the objective
exposure (such as amount of change, or physical
exertion) carry the greatest weight in the teratogenic
effects, then public health and safety personnel may
need to ensure that pregnant women exposed to a
natural disaster are sent immediately to very safe areas
rather than being moved several times. If, however, it is
found that the greatest harm to the foetus results from
the mother’s physiological hyperarousal following a
disaster, then psychological (e.g. biofeedback) or
pharmacological interventions may be warranted to
limit damage to the foetus. Thus, projects such as
Project Ice Storm will assist in, first, identifying the most
vulnerable subgroups of pregnant women and,
secondly, lead to recommendations targeted at limit-
ing damage.
This study was funded by grants from the Stairs
Memorial Fund, the Quebec Mental Health Research
Network, the Canadian Psychiatric Research Foun-
dation, and the Canadian Institutes of Health
Research, to the first author, and by a grant from the
Schizophrenia Axis of the Fonds de la recherche
en sante
du Que
bec’s Network on Mental Health
Research to the second author. The first author is also
a recipient of a salary award from the Quebec Health
Research Fund (FRSQ).
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Effects of prenatal maternal stress 45
... A systematic review has found that exposure to disasters increases cardiometabolic risk, including obesity, across the life course, however, research has not yet explored how obesity may influence stress experienced during a disaster [17]. Stress during a disaster can be measured objectively, using reports of stressors, or subjectively, measuring perceptions of a disaster [18]. ACEs are an established risk factor for both stress [5][6][7] and later life obesity [4,8]. ...
... Stress was measured in two ways: (1) stressors and (2) the perceived consequences of the pandemic. These questions have previously been used in disaster research [18,[34][35][36] to study objective and subjective stress following a disaster such as the COVID-19 pandemic. The development of these questions were modified from gold-standard measurement tools [18]. ...
... These questions have previously been used in disaster research [18,[34][35][36] to study objective and subjective stress following a disaster such as the COVID-19 pandemic. The development of these questions were modified from gold-standard measurement tools [18]. ...
Full-text available
Background People with obesity are at increased risk of chronic stress, and this may have been exacerbated during the COVID-19 pandemic. Adverse childhood experiences (ACE) are also associated with both obesity and stress, and may modify risk of stress among people with obesity. The objectives of this study were to evaluate the associations between obesity, ACEs, and stress during the pandemic, and to determine if the association between obesity and stress was modified by ACEs. Methods A longitudinal study was conducted among adults aged 50–96 years ( n = 23,972) from the Canadian Longitudinal Study on Aging (CLSA) COVID-19 Study. Obesity and ACEs were collected pre-pandemic (2015–2018), and stress was measured at COVID-19 Exit Survey (Sept-Dec 2020). We used logistic, Poisson, and negative binomial regression to estimate relative risks (RRs) and 95% confidence intervals (CIs) for the associations between obesity, ACEs, and stress outcomes during the pandemic. Interaction by ACEs was evaluated on the additive and multiplicative scales. Results People with obesity were more likely to experience an increase in overall stressors (class III obesity vs. healthy weight RR = 1.19; 95% CI: 1.12–1.27) as well as increased health related stressors (class III obesity vs. healthy weight RR: 1.25; 95% CI: 1.12–1.39) but did not perceive the consequences of the pandemic as negative. ACEs were also associated an increase in overall stressors (4–8 ACEs vs. none RR = 1.38; 95% CI: 1.33–1.44) and being more likely to perceive the pandemic as negative (4–8 ACEs vs. none RR = 1.32; 95% CI: 1.19–1.47). The association between obesity and stress was not modified by ACEs. Conclusions Increased stress during the first year of the COVID-19 pandemic was observed among people with obesity or ACEs. The long-term outcomes of stress during the pandemic need to be determined.
... Hurricane Harvey-related objective hardship Mothers' flood-related objective hardship was reported retrospectively at baseline using a questionnaire similar to that used by our team in previous disaster-related prenatal maternal stress research King & Laplante, 2005) that was modified specifically for Hurricane Harvey. Items were written in objective terms and assessed four key dimensions of flood exposure: threat (e.g., personal injury), loss (e.g., loss of personal income), scope (e.g., days were you without electricity), and change (e.g., time spent in a temporary shelter). ...
Full-text available
Prenatal maternal stress and mental health problems are known to increase risk for developmental psychopathology in offspring, yet pathways leading to risk or resiliency are poorly understood. In a quasi-experimental design, we prospectively examined associations between disaster-related prenatal stress, maternal mental health symptoms, and infant temperament outcomes. Mothers who were pregnant during Hurricane Harvey (N = 527) reported on objective hardships (e.g., loss of belongings or income, evacuation, home flooding) related to the storm and subsequent mental health symptoms (anxiety/depression, posttraumatic stress) across time. At a postpartum assessment, mothers reported on their infant's temperament (negative affect, positive affect, orienting/regulatory capacity). Greater objective hardship indirectly predicted higher levels of infant orienting/regulatory capacity through its association with increased maternal posttraumatic stress symptoms. Greater objective hardship also indirectly predicted higher levels of infant negative affect through its association with increased maternal anxiety/depression symptoms across time. Our findings suggest a psychological mechanism linking prenatal stress with specific temperamental characteristics via maternal mental health symptoms. Findings point to the importance of high-quality assessment and mental health services for vulnerable women and young children.
... Current findings suggest that the potential negative effects of PRS per se-even in absence of antenatal exposure to SARS-CoV-2 infection-on offspring's development are likely to persist until 12 months after childbirth. Furthermore, while previous research on the effects of maternal prenatal stress mainly reported on emotional [43,44] and cognitive [13,45] infant outcomes, here we suggest that a precocious marker of altered developmental trajectory as consequence of adversity exposure during pregnancy might be traced in the early delay or deficit in specific socio-cognitive behaviors. Mechanisms ...
Full-text available
Background: Prenatal maternal stress is a key risk factor for infants' development. Previous research has highlighted consequences for infants' socio-emotional and cognitive outcomes, but less is known for what regards socio-cognitive development. In this study, we report on the effects of maternal prenatal stress related to the COVID-19 pandemic on 12-month-old infants' behavioral markers of socio-cognitive development. Methods: Ninety infants and their mothers provided complete longitudinal data from birth to 12 months. At birth, mothers reported on pandemic-related stress during pregnancy. At infants' 12-month-age, a remote mother-infant interaction was videotaped: after an initial 2-min face-to-face episode, the experimenter remotely played a series of four auditory stimuli (2 human and 2 non-human sounds). The auditory stimuli sequence was counterbalanced among participants and each sound was repeated three times every 10 seconds (Exposure, 30 seconds) while mothers were instructed not to interact with their infants and to display a neutral still-face expression. Infants' orienting, communication, and pointing toward the auditory source was coded micro-analytically and a socio-cognitive score (SCS) was obtained by means of a principal component analysis. Results: Infants equally oriented to human and non-human auditory stimuli. All infants oriented toward the sound during the Exposure episode, 80% exhibited any communication directed to the auditory source, and 48% showed at least one pointing toward the sound. Mothers who reported greater prenatal pandemic-related stress had infants with higher probability of showing no communication, t = 2.14 (p = .035), or pointing, t = 1.93 (p = .057). A significant and negative linear association was found between maternal prenatal pandemic-related stress and infants' SCS at 12 months, R2 = .07 (p = .010), while adjusting for potential confounders. Conclusions: This study suggests that prenatal maternal stress during the COVID-19 pandemic might have increased the risk of an altered socio-cognitive development in infants as assessed through an observational paradigm at 12 months. Special preventive attention should be devoted to infants born during the pandemic.
... Maternity care is ultimately one of the most early and important points of intervention for the population's physical and mental health across the lifespan. Studies in other extreme examples such as those following children of mothers that were pregnant during natural disasters have shown disturbingly high levels of internalizing and externalizing problems such as ADHD, depression, and anxiety, as well as poorer language and cognitive development in the children that were exposed to natural disasters in-utero [59][60][61]. Environmental stress is known to impact the long-term health of a developing fetus through a number of mechanisms including epigenetics (changes to developmental programming) and shortening of telomeres (an important protective component at the end of chromosomes) [58]. In these various ways, right down to the cellular level, environmental stress in-utero can have long-term health effects by changing the programming of organs, tissues, and body system structures. ...
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Globally, the impact of COVID-19 on mental health has been significant. Pregnant women are known to be a vulnerable population in relation to mental health. In Australia, there was an unprecedented demand during the pandemic for mental health services, including services for pregnant women. Maternal mental health has unique and enduring features that can significantly shape a child’s overall development and poor maternal mental health can have considerable social and economic costs. This cross-sectional study evaluated symptoms of antenatal depression and COVID-19-related distress in a sample of two hundred and sixty-nine pregnant women residing in Australia aged between 20 and 43 (M = 31.79, SD = 4.58), as part of a larger study. Social media advertising was used to recruit participants between September 2020 and November 2021. Prevalence rates for antenatal depression were found to be higher in this study (16.4%) compared with previous Australian prevalence rates (7%). COVID-19 distress in relation to having a baby during a COVID-19 outbreak significantly predicted symptoms of antenatal depression, B = 1.46, p < 0.001. Results from this study suggest that mothers and families may have increased mental health vulnerabilities as a consequence of the pandemic for some time yet.
This longitudinal study compared infant temperament rated at 3 months postpartum by 263 United-States-based women who gave birth during the COVID-19 pandemic and 72 who gave birth prior to the pandemic. All women completed questionnaires assessing perinatal mental health, social contact, and infant temperament. Mothers whose infants were born during the pandemic reported higher levels of infant negative affectivity as compared with mothers whose infants were born earlier (F(1, 324) = 18.28, p < .001), but did not differ in their ratings of surgency or effortful control. Maternal prenatal depressive symptoms, prenatal stress, and postpartum stress mediated differences in infant negative affectivity between pandemic and pre-pandemic groups. Within the pandemic group, decreased postpartum social contact was associated with higher ratings of infant negative affectivity. These findings suggest that the pandemic has affected maternal perceptions of infant temperament, perinatal mental health, and social contact.
Schizophrenia is caused by interaction of a combination of genetic and environmental factors. Of the latter, prenatal exposure to maternal stress is reportedly associated with elevated disease risk. The main orchestrators of inflammatory processes within the brain are microglia, and aberrant microglial activation/function has been proposed to contribute to the aetiology of schizophrenia. Here, we evaluate the epidemiological and preclinical evidence connecting prenatal stress to schizophrenia risk, and consider the possible mediating role of microglia in the prenatal stress-schizophrenia relationship. Epidemiological findings are rather consistent in supporting the association, albeit they are mitigated by effects of sex and gestational timing, while the evidence for microglial activation is more variable. Rodent models of prenatal stress generally report lasting effects on offspring neurobiology. However, many uncertainties remain as to the mechanisms underlying the influence of maternal stress on the developing foetal brain. Future studies should aim to characterise the exact processes mediating this aspect of schizophrenia risk, as well as focussing on how prenatal stress may interact with other risk factors.
The in utero environment influences fetal development and may predispose to disease later in life. This study examines whether maternal suicidal ideation during pregnancy is associated with children's behavioral trajectories across early childhood, and whether prenatal maternal traumatic stress accelerates the trajectories. The study included mother-child dyads (N = 331, 51.1% boys) from the longitudinal Stress In Pregnancy study; 31.1% (n = 103) mothers were Exposed to Superstorm Sandy. During their second trimester, 12.4% (n = 41) women reported suicidal ideation during pregnancy. Mothers completed the Behavior Assessment Scale for Children-2 annually from ages 2- to 6-years-old to assess multiple behavioral domains. Hierarchical linear modeling estimated within-person longitudinal trajectories of clinical behaviors, and between-person effects of maternal suicidal ideation and disaster-related stress in utero on changes in child behavior. For children exposed to both risks, Atypical behaviors (i.e., unusual behaviors, social disconnection) increased linearly across early childhood. Exposure to Superstorm Sandy and maternal suicidal ideation were independently associated with non-linear increases in Anxiety severity and maternal suicidal ideation during pregnancy was associated with a linear increase in Attention problems across early childhood. Maternal suicidal ideation during pregnancy is associated with increased risk for a range of behavioral and emotional difficulties in early childhood and the trajectory of atypical behaviors was amplified by disaster-related traumatic stress. Findings highlight the need for health professionals to screen for suicidal ideation among their pregnant patients. Pregnant women who experience severe stress may require additional monitoring and support to reduce risk for poorer early childhood outcomes.
Little is known about the role of hypothalamic-pituitary-adrenal (HPA) axis functioning for children's cognitive development, especially among vulnerable groups. The current study explores the relationship between diurnal cortisol slope and cognitive outcomes among children at the ages of 5 and 6 who have been maltreated as infants and involved with child protective services, using data from the National Survey of Child and Adolescent Well-Being (NSCAW) I (N=158). Multiple regression analyses showed that a greater decline in salivary cortisol from morning to evening was positively associated with scores on applied problems and expressive communication, even after adjustment for confounding. It was also associated with lower odds of cognitive disability. There were null associations with letter-word identification, passage comprehension, auditory comprehension, matrices, and vocabulary. Results suggest that children involved with child protective services as infants, and thus exposed early to likely 'toxic' levels of stressors, may face dysregulation of the HPA axis and particular difficulties in some aspects of cognitive function. Potential explanations and implications for policy are discussed.
Finding a unifying concept behind the diversity of signs and symptoms in schizophrenia is a central challenge to contemporary research. A neo-Bleulerian unitary model is described, which defines the illness as a neurodevelopmentally derived "misconnection syndrome," involving connections between cortical regions and the cerebellum mediated through the thalamus (the cortico-cerebellar-thalamic-cortical circuit [CCTCC]). An abnormality in this circuitry, normally used to coordinate both motor and mental activity, leads to misconnections in many aspects of mental activity, or "cognitive dysmetria." As Bleuler originally proposed, "thought disorder" is the primary defining feature of schizophrenia, rather than the more obvious signs and symptoms such as delusions and hallucinations. Cognitive dysmetria, or a disorder in the CCTCC, may provide a heuristic theoretical framework for strategies to explore etiology, pathophysiology, intervention, or prevention.
• In the context of a Finnish birth cohort, we tested the hypothesis that viral infection during the latter two thirds of fetal development would increase the risk of adult schizophrenic outcome. Psychiatric hospital diagnoses were recorded for all individuals in greater Helsinki who were fetuses during the 1957 type A2 influenza epidemic. Those exposed to the viral epidemic during their second trimester of fetal development were at elevated risk of being admitted to a psychiatric hospital with a diagnosis of schizophrenia. This was true for both males and females and independently in several psychiatric hospitals. The second-trimester effect was seen in the elevated proportion of schizophrenics among those admitted to a psychiatric hospital and also in higher rates of schizophrenia per 1000 live births in the city of Helsinki. The study has several limitations: (1) We have no direct evidence that the subjects actually suffered a viral Infection. (2) The psychiatric data were obtained only for subjects up to the age of 26 years, 56 days. (3) The findings are based on hospital diagnoses. (4) The determination of stage of gestation at time of exposure to the epidemic is based on date of birth. The viral Infection might have occurred outside the official epidemic window; the infant may have had a preterm or postterm delivery. These sources of error, however, should not serve to enhance the findings. The observed viral effect is interpreted as being one of many potential perturbations of gestation. We suggest that It is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.