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Anti-inflammatory and immunomodulatory activities of the extracts from the inflorescence of Chrysanthemum indicum Linné. J Ethnopharmacol 101(1-3):334-337

Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
Journal of Ethnopharmacology (Impact Factor: 3). 11/2005; 101(1-3):334-7. DOI: 10.1016/j.jep.2005.04.035
Source: PubMed

ABSTRACT

Chrysanthemum indicum Linné (CI) has a long history for the treatment of inflammation, hypertension and respiratory diseases in China. The purpose of the present study was to investigate the anti-inflammatory and immunomodulatory properties of the inflorescence or bud of CI extracts. The ethanol extract of CI (CIEE) was fractionated to a petroleum ether soluble fraction (CIPF), an ethyl acetate soluble fraction (CIEF), a butanol soluble fraction (CIBF) and a water soluble fraction (CIWF) successively. CIBF (150 mg/kg, p.o.) caused a significant inhibition on the auricle edema in mice. CIBF (150, 300 mg/kg, p.o.) not only significantly increased the delayed-type hypersensitivity (DTH) reaction induced by 2,4-dinitro-fluorobenzene (DNFB) but also significantly enhanced antibody generation by splenic cells of mice and IgG and IgM levels in mice sera in response to sheep red blood cells (SRBC) in cyclophosphamide (CP)-induced mice. Furthermore, CIBF (150, 300 mg/kg, p.o.) obviously potentiated the function of the mononuclear phagocytic system in CP-induced mice. The above results reveal that CIBF possesses anti-inflammatory, humoral and cellular immunomodulatory and mononuclear phagocytic activities, probably due to the presence of flavonoids.

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    • "For example, C. morifolium, which is widely used in China as a dietary supplement [2] [3], has been shown to exhibit antihepatotoxic and antigenotoxic effects [4]. In addition, C. indicum, a traditional herb that is widely used in Korea and Japan, has been found to possess anti-inflammatory, immunomodulatory, humoral and cellular , and mononuclear phagocytic activities [5] [6]. Also, the flowers of C. cinerariaefolium and C. macrotum were proven to have insecticidal and herbicide activities [1] [7]. "
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    ABSTRACT: The essential oil of the Jordanian Chrysanthemum coronarium L. (garland) was isolated by hydrodistillation from dried flowerheads material. The oil was essayed for its in vitro scavenging activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. The results demonstrate that the oil exhibits moderate radical scavenging activity relative to the strong antioxidant ascorbic acid. In addition, cholinesterase inhibitory activity of C. coronarium essential oil was evaluated for the first time. Applying Ellman’s colorimetric method, interesting cholinesterase inhibitory activity, which is not dose dependent, was evident for the oil. Furthermore, antimicrobial activities of the oil against both Gram-negative and Gram-positive bacteria were evaluated. While it fails to inhibit Gram-negative bacteria growth, the antibacterial effects demonstrated by the oil were more pronounced against the Gram-positive strains. Moreover, the examined oil was assessed for its in vitro antiproliferative properties where it demonstrated variable activities towards different human cancer cell lines, of which the colon cancer was the most sensitive to the oil treatment.
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    • "Although the evidence of risk in longer use is unknown, but the acute toxic results sufficiently support the fact that BtOH and EtOAc fractions of NAF have no toxicity. Xylene-induced ear edema in mice is a preliminary and simple acute inflammation model for evaluating potential antiinflammatory agents (Cheng et al., 2005). Ear edema may involve inflammatory mediators such as histamine, kinin, fibrinolysin, phospholipase A2 and PLA2. "
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    • "Oriental Chrysanthemum indicum traditional medicine has been used to treat vertigo, hypertensive symptoms and several infectious diseases such as pneumonia, colitis, stomatitis and carbuncles [5]. A series of studies have demonstrated that Chrysanthemum indicum possesses antimicrobial [6], anti-inflammatory [6] [7] [8], immunomodulatory[7], and neuroprotective effects[9]. Recently, much attention has been devoted to the anticancer activity of Chrysanthemum indicum on human PC3, HL 60 and HeLa cancer cells in a dose-and time-dependent manner [10] [11] [12]. "

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