The effect of the homeopathic remedies Arnica montana and Bellis perennis on mild postpartum bleeding - A randomized, double-blind, placebo-controlled study - Preliminary results

The Center for Integrative Complementary Medicine, Shaare Zedek Medical Center, Jerusalem 91031, Israel.
Complementary Therapies in Medicine (Impact Factor: 1.55). 06/2005; 13(2):87-90. DOI: 10.1016/j.ctim.2005.03.006
Source: PubMed


To evaluate the effect of Arnica Montana and Bellis perennis on postpartum blood loss.
Double blind, placebo-controlled, randomized, clinical trial.
Department of Gynecology, Shaare Zedek Medical Center, Jerusalem.
Forty parturients were randomized to one of three groups: Arnica montana C6 and Bellis perennis C6 (n=14), Arnica montana C30 and Bellis perennis C30 (n=14), or double placebo (n=12). After 48 h the Arnica/placebo was halted, and patients continued the Bellis/placebo until cessation of lochia.
Hemoglobin levels (Hb) at 48 and 72 h postpartum.
At 72 h postpartum, mean Hb levels remained similar after treatment with homeopathic remedies (12.7 versus 12.4) as compared to a significant decrease in Hb levels in the placebo group (12.7 versus 11.6; p<0.05), in spite of less favorable initial characteristics of the treatment group. The mean difference in Hb levels at 72 h postpartum was -0.29 (95% CI -1.09; 0.52) in the treatment group and -1.18 (95% CI -1.82; -0.54) in the placebo group (p<0.05).
Treatment with homeopathic Arnica montana and Bellis perennis may reduce postpartum blood loss, as compared with placebo.

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Available from: Menachem Oberbaum
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    • "The main constituents are triterpenoid saponins (Hiller et al., 1988; Schopke et al., 1991; Li et al., 2005; Morikawa et al., 2008; Yoshikawa et al., 2008), essential oils (Avato et al., 1997; Kavalcioglu et al., 2010) and flavonoids (Gudej & Nazaruk, 2001). Antibacterial (Avato et al., 1997; Kavalcioglu et al., 2010), antifungal (Desevedavy et al., 1989; Avato et al., 1997; Kavalcioglu et al., 2010), antihyperlipidemic (Morikawa et al., 2010a), antioxidant (Kavalcioglu et al., 2010), postpartum antihemorrhagic (Oberbaum et al., 2005), pancreatic lipase inhibitor (Morikawa et al., 2010b) and cytotoxic activities against HL-60 human promyelocytic leukemia cells (Li et al., 2005) of B. perennis have also been investigated. Wound healing involves a series of events namely chemotaxis, cell division, revascularization, synthesis of new extracellular matrix, and the formation and remodeling of the scar tissue (Hanna & Giacopelli, 1997). "
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    ABSTRACT: Bellis perennis L. (Asteraceae) has been used traditionally in the treatment of bruises, broken bones, and wounds by European people. To investigate the wound healing activity of B. perennis flowers in Wistar albino rats. Dried B. perennis flowers were extracted with ethanol, then fractioned with n-butanol and an oinment was prepared. Twelve male adult Wistar rats were used. Six wounds were created for each animal by using circular excision wound model. The first two wounds were treated topically with HOTBp (hydrophilic ointment treatment containing n-butanol fraction). The second two wounds were control group and not treated with anything. The third two wounds were treated only with HOT (hydrophilic ointment treatment without n-butanol fraction). Treatments were applied once a day and lasted for 30 days. Wound samples were excised on days 5(th), 10(th) and 30(th). The percentage of wound healing was calculated by Walker's formula after measurement of the wound area and the tissue samples were examined histopathologically. The percentages of wound closure (HOTBp: 100%; HOT: 85% and control: 87%) and histopathological observations showed that there were statistically significant differences between HOTBp, HOT and control groups (p < 0.05) at 30(th) day. Topically administered ointment prepared from the n-butanol fraction of B. perennis flowers has a wound healing potential without scar formation in circular excision wound model in rats. Thus, traditional usage of wound healing activity of B. perennis was scientifically verified for the first time.
    Full-text · Article · Aug 2012 · Pharmaceutical Biology
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    • "Homeopaths encounter similar dilemmas with treatments such as Arnica. That is, clinical experience tells them the remedy is helpful in many first aid situations, but the research literature shows mixed results (for many reasons, especially involving study design), with many negative studies showing Arnica of no benefit (Ernst & Pittler, 1998; W. Jonas, Lin, Y., Williams, A., Tortella, F., Tuma, R., 1999; Oberbaum et al., 2005; Ramelet, Buchheim, Lorenz, & Imfeld, 2000; Stevinson, Devaraj, Fountain-Barber, Hawkins, & Ernst, 2003). When clinicians have the opportunity to look at the details of each study, they usually can point out glaring problems with a mismatch between clinical practice and the actual study design – in terms of choice of clinical condition, remedy, and dosing schedule. "

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    ABSTRACT: The effects of aqueous extract of flowers from Bellis perennis on anxiety-like behavior and memory in Wistar rats were tested. Vehicle 20 and 60 mg kg -1 B. perennis groups were performed and the animals were tested by open field and elevated plus maze tests for anxiety-like behaviour and Morris water maze test for spatial memory. In the open field, the high dose of B. perennis administrated rats spent more time at the center, showed less mobility and velocity. In the elevated plus maze, the high dose of B. perennis administrated rats spent more time in the open arms, spent less time in the closed arms, were less mobile, were slower and rotated less frequently. In the Morris water maze, the high dose of B. perennis administrated rats spent more of the time to find the platform. In conclusion, B. perennis may produce biphasic effects on both anxiety-like behaviour and learning performance of the rats.
    Preview · Article · Sep 2011 · African journal of pharmacy and pharmacology
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