Pharmacokinetics of Nelfinavir and Efavirenz in Antiretroviral-Naive, Human Immunodeficiency Virus-Infected Subjects when Administered Alone or in Combination with Nucleoside Analog Reverse Transcriptase Inhibitors

Harvard University, Cambridge, Massachusetts, United States
Antimicrobial Agents and Chemotherapy (Impact Factor: 4.48). 09/2005; 49(8):3558-61. DOI: 10.1128/AAC.49.8.3558-3561.2005
Source: PubMed


Pharmacokinetic studies were conducted with human immunodeficiency virus-infected patients receiving efavirenz, nelfinavir,
or both agents at weeks 4 and 32. Reductions of 25% and 45% were observed in the mean nelfinavir area under the concentration-time
curve and minimum concentration of the drug in serum, and there was a 31% more rapid half-life for patients receiving both
drugs compared to patients receiving nelfinavir alone. There were no significant differences in efavirenz pharmacokinetics.


Available from: Hulin Wu, Feb 19, 2015
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