The relationship between serum resistin, leptin, adiponectin, ghrelin levels and bone mineral density in middle-aged men

Division of Endocrinology and Metabolism, Department of Internal Medicine, Sacred Heart Hospital, Hallym University, Pyungchon-dong, Dongan-gu, Anyang-city, Kyungki-do, Chunchon, Korea.
Clinical Endocrinology (Impact Factor: 3.46). 09/2005; 63(2):131-8. DOI: 10.1111/j.1365-2265.2005.02312.x
Source: PubMed


Body weight is a significant predictor of bone mass. Hormonal factors such as sex hormones, insulin, leptin and adiponectin are thought to play a role in the mechanisms controlling the association of body weight and fat mass with bone mass. However, contradictory results have been reported for the association between serum adipocytokines and bone mineral density (BMD). We therefore examined whether the serum adipocytokine and ghrelin levels, markers of fat metabolism, are associated with BMD in male adults.
For 80 male adults (average age 54.5 +/- 6.4 years; average body mass index (BMI) 24.4 +/- 2.5 kg/m2), the correlations between serum resistin, leptin, adiponectin and ghrelin levels with BMD were investigated.
Among the adipocytokines, serum resistin levels were negatively correlated with lumbar spine BMD (r = -0.237, P = 0.05). After adjustment was made for age and BMI, log-transformed serum leptin showed a significant negative correlation with lumbar spine BMD, which was not seen on bivariate analysis (r = -0.237, P = 0.039). Femoral neck BMD was marginally associated only with serum adiponectin levels (r = -0.226, P = 0.062). In multiple regression analyses, among the adipokines, only resistin was a significant determinant of lumbar spine BMD, although the variance was small (R2 = 0.256). Serum ghrelin levels were not correlated with the BMD of either body site.
Serum resistin level showed a significant negative correlation with lumbar spine BMD, although the variance was small. Further studies are needed to elucidate the role of adipocytokines in bone metabolism.

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Available from: Eun-Jung Rhee, Jan 23, 2016
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    • "Generally , it seems that adiponectin is not a determinant for BMD. Although adiponectin increases osteoblast differentiation through increasing cyclooxygenase-2 expression in fat tissue [57], various investigations, including our study, show no significant association between adiponectin and BMD [53] [58]. Leptin that is released by adipose tissue is strongly correlated with fat mass [59]. "
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    • "There was no significant association between ghrelin and BMD in a study consisting of 80 male adults. In this study, the effect of alcohol, smoking, and physical activity was not controlled [13]. Also, in a study with 977 old adults, no significant association was found between ghrelin and BMD in either sex after controlling for age and BMI [15]. "
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    • "Also they found that serum adiponectin levels were not significantly different between the patients with osteoporotic fractures and nonosteoporotic fractures [13–16]. However, most of the researches showed a negative correlation between adiponectin and BMD [17–23]. In a META analysis including 59 studies, a great inverse correlation between adiponectin levels and BMD independent of gender and menopausal status was found. "
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