Incidence of Severe Rotavirus Diarrhea in New Delhi, India, and G and P Types of the Infecting Rotavirus Strains

Center for Diarrheal Disease and Nutrition Research, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi.
The Journal of Infectious Diseases (Impact Factor: 6). 09/2005; 192 Suppl 1(s1):S114-9. DOI: 10.1086/431497
Source: PubMed


A total of 62,475 children <5 years old from a defined population of approximately 500,000 children and adults from slums in New Delhi, India, were assessed for 1 year by means of passive surveillance, to identify children who were hospitalized for diarrhea. The incidence of severe rotavirus diarrhea was estimated, and the G and P types of the infecting rotavirus strains were determined and were correlated with the clinical severity of diarrhea. Of 584 children who were hospitalized with diarrhea, 137 (23.5%) had rotavirus detected in stool specimens (incidence of rotavirus diarrhea-associated hospitalizations, 337 hospitalizations/100,000 children <5 years of age). Most cases of diarrhea (98%) occurred during the first 2 years of life, peaking at 9-11 months of age. Rotavirus-associated diarrhea occurred year-round but was predominant in winter. Among the strains that could be G-typed, G1 was the most common serotype, followed by G9 and G2; 10% of cases of diarrhea were due to mixed G-type infections. Common strains identified in the present surveillance study were P[8]G1, P[4]G2, P[8]G9, P[6]G1, P[6]G9, and P[6]G3. Children infected with G1 strains had a greater risk of developing more-severe cases of diarrhea than did children infected with other rotavirus strains (odds ratio, 2.95; 95% confidence interval, 1.3-6.67).

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Available from: Swati Subodh, Oct 01, 2015
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    • "Rotavirus associated morbidity in India is also well documented. Many Indian studies including the Indian Rotavirus Strain Surveillance Network (IRSN) have evaluated RVGE burden amongst hospitalized cases of acute gastroenteritis (AGE) and some studies also demonstrated rotaviruses strain diversity as in other developing countries [2] [3] [4] [5] [6]. These hospital based studies included testing stool samples for rotavirus and to determine the causative rotavirus strains. "
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    • "Diarrhea has been estimated to cause 1.5 million deaths and 21% of deaths worldwide in children under the age of 5 [4]. In India, most cases of diarrhea (98%) occurred during the first 2 years of life, peaking at 9–11 months [2]. Based on a literature review of studies published between 1986 and 1999 on childhood deaths caused by diarrhea and hospitalizations due to rotavirus, it was estimated that 440,000 annual deaths in children aged <5 years occur because of rotavirus infection [1]. "
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    • "In the tropics the pattern seems to be less obvious, but peaks are more common during the spring and autumn months. In India rotavirus is endemic throughout the year, however peaks within the years occur usually during the winter months (Bahl et al., 2005; Purohit et al., 1998). We therefore focussed only on the winter months (December–February) to estimate the impact of climate change on rotavirus incidences for our future projections. "
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