Epidemiology and Transmission Dynamics of West Nile Virus Disease

Centers for Disease Control and Prevention, Fort Collins, Colorado 80526, USA.
Emerging infectious diseases (Impact Factor: 6.75). 08/2005; 11(8):1167-73. DOI: 10.3201/eid1108.050289a
Source: PubMed


From 1937 until 1999, West Nile virus (WNV) garnered scant medical attention as the cause of febrile illness and sporadic encephalitis in parts of Africa, Asia, and Europe. After the surprising detection of WNV in New York City in 1999, the virus has spread dramatically westward across the United States, southward into Central America and the Caribbean, and northward into Canada, resulting in the largest epidemics of neuroinvasive WNV disease ever reported. From 1999 to 2004, >7,000 neuroinvasive WNV disease cases were reported in the United States. In 2002, WNV transmission through blood transfusion and organ transplantation was described for the first time, intrauterine transmission was first documented, and possible transmission through breastfeeding was reported. This review highlights new information regarding the epidemiology and dynamics of WNV transmission, providing a new platform for further research into preventing and controlling WNV disease.

Download full-text


Available from: Nicholas Komar, Feb 02, 2015
  • Source
    • "The passive system of reporting of equine cases by sentinel veterinarians in France was found to be a cost-effective and efficient method of early detection of virus activity when compared to sentinel horses, sentinel chickens, and mosquito testing by using mathematical modeling to simulate data for low activity and endemic and epidemic situations (Chevalier et al. 2011). Although equines frequently are vaccinated in California (American Association of Equine Practitioners 2012) and, therefore, our horse population has not experienced the recent epizootics seen in France (Hayes et al. 2005), our results for areas with a susceptible bird population agree that passive surveillance is the most cost-effective system for WNV surveillance. Higher densities of mosquito traps resulted in more precise estimates of infection prevalence in both trap types. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Surveillance systems for West Nile virus (WNV) combine several methods to determine the location and timing of viral amplification. The value of each surveillance method must be measured against its efficiency and costs to optimize integrated vector management and suppress WNV transmission to the human population. Here we extend previous comparisons of WNV surveillance methods by equitably comparing the most common methods after standardization on the basis of spatial sampling density and costs, and by estimating optimal levels of sampling effort for mosquito traps and sentinel chicken flocks. In general, testing for evidence of viral RNA in mosquitoes and public-reported dead birds resulted in detection of WNV approximately 2-5 weeks earlier than serological monitoring of sentinel chickens at equal spatial sampling density. For a fixed cost, testing of dead birds reported by the public was found to be the most cost effective of the methods, yielding the highest number of positive results per $1000. Increased spatial density of mosquito trapping was associated with more precise estimates of WNV infection prevalence in mosquitoes. Our findings also suggested that the most common chicken flock size of 10 birds could be reduced to six to seven without substantial reductions in timeliness or sensitivity. We conclude that a surveillance system that uses the testing of dead birds reported by the public complemented by strategically timed mosquito and chicken sampling as agency resources allow would detect viral activity efficiently in terms of effort and costs, so long as susceptible bird species that experience a high mortality rate from infection with WNV, such as corvids, are present in the area.
    Full-text · Article · Feb 2015 · Vector borne and zoonotic diseases (Larchmont, N.Y.)
    • "Public health Figure 1. Culex quinquefasciatus collection sites within 5 km buffer zones around sentinel chicken traps.P r o o f cern has continued to surface over mosquitoborne diseases since the first domestic case of West Nile virus (WNV) was recorded in New York in 1999 (Hayes et al. 2005). West Nile virus was first reported in St. Johns County in 2001 (Connelly et al. 2012). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Arbovirus surveillance program conducted by Anastasia Mosquito Control District is the early monitoring system to detect vector borne diseases. The sporadic frequency and intensity of Eastern Equine Encephalitis (EEE) and West Nile viruses (WNV) in St. Johns County prompted the development of spatial analysis to understand their geographic distribution in the county. Geographic Information System toolboxes were proven as a successful method in studying and predicting the geographic distribution pattern of mosquito borne disease. Data on frequency and intensity of EEE, WNV and their mosquito vectors, Culiseta melanura and Culex quinquefasciatus, for the time period 2008-2014 was used to assess their standard deviational ellipsoid, standard distance, and spatial autocorrelation using spatial statistics toolbox in ArcGIS software (ver. 10.0). Also, logistic regression analysis was used to evaluate the dependency of diseases occurrence records on their mosquito vectors abundance. The frequency/intensity of both diseases and their vectors were shown to be randomly distributed in space. Also, a significant reduced dependency of EEE and WNV on their vectors density was proven by the statistical analysis. The significance of geographic information system application in surveillance programs stems from its potentiality in delineating the spatial distribution patterns and directional trends of diseases and producing probability maps for areas under risk. Eventually, the risk maps will help in maximizing the potentiality of targeted surveillance and control programs, which will reduce the cost benefit, labor and time consumed.
    No preview · Article · Jan 2015
  • Source
    • "However, its importance is likely to be higher outside urban areas where their preferred breeding sites are more common and the abundance of wild animals is higher. Outside of Austria, Ae. vexans has been shown to serve as a vector for WNV (USA; Hayes et al. 2005) and for dirofilariasis (Slovakia; Bocková et al. 2013). Similar to Ae. vexans, the preferred breeding sites of Oc. sticticus are temporary water bodies after floodings (Becker et al. 2010). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Mosquitoes (Diptera: Culicidae) are important vectors for a wide range of pathogenic organisms. As large parts of the human population in developed countries live in cities, the occurrence of vector-borne diseases in urban areas is of particular interest for epidemiologists and public health authorities. In this study, we investigated the mosquito occurrence in the city of Vienna, Austria, in order to estimate the risk of transmission of mosquito-borne diseases. Mosquitoes were captured using different sampling techniques at 17 sites in the city of Vienna. Species belonging to the Culex pipiens complex (78.8 %) were most abundant, followed by Coquillettidia richiardii (10.2 %), Anopheles plumbeus (5.4 %), Aedes vexans (3.8 %), and Ochlerotatus sticticus (0.7 %). Individuals of the Cx. pipiens complex were found at 80.2 % of the trap sites, while 58.8 % of the trap sites were positive for Cq. richiardii and Ae. vexans. Oc. sticticus was captured at 35.3 % of the sites, and An. plumbeus only at 23.5 % of the trap sites. Cx. pipiens complex is known to be a potent vector and pathogens like West Nile virus (WNV), Usutu virus (USUV), Tahyna virus (TAHV), Sindbis virus (SINV), Plasmodium sp., and Dirofilaria repens can be transmitted by this species. Cq. richiardii is a known vector species for Batai virus (BATV), SINV, TAHV, and WNV, while Ae. vexans can transmit TAHV, USUV, WNV, and Dirofilaria repens. An. plumbeus and Oc. sticticus seem to play only a minor role in the transmission of vector-borne diseases in Vienna. WNV, which is already wide-spread in Europe, is likely to be the highest threat in Vienna as it can be transmitted by several of the most common species, has already been shown to pose a higher risk in cities, and has the possibility to cause severe illness.
    Full-text · Article · Dec 2014 · Parasitology Research
Show more