Molarless-induced changes of spines in hippocampal region of SAMP8 mice

Article · October 2005with1 Reads
DOI: 10.1016/j.brainres.2005.07.038 · Source: PubMed
We examined the effect of the molarless condition on the dendritic spines of hippocampal pyramidal cells in SAMP8 mice in comparison to its effect on learning ability in a maze test. The molarless condition caused a decrease in the number of the spines of CA1 pyramidal cells only in the aged mice showing a reduced learning ability. The results suggest the involvement of the molarless condition in an attenuation of input activities in the hippocampal synapses.
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