Idiopathic Chronic Urticaria and Celiac Disease

Department of Internal Medicine, Catholic University the Sacred Heart, Rome, Italy.
Digestive Diseases and Sciences (Impact Factor: 2.61). 10/2005; 50(9):1702-4. DOI: 10.1007/s10620-005-2919-8
Source: PubMed


Idiopathic chronic urticaria (ICU) is a chronic relapsing cutaneous disease. Some case reports or studies on small series of celiac disease (CD) patients have suggested a possible association between CD and ICU. The aim of this study was to assess the prevalence of CD in a population of adults ICU patients with respect to healthy controls. We consecutively enrolled 80 patients affected by ICU and 264 blood donors as the control population without a history of ICU. Serum anti-transglutaminase IgG and anti-endomysium IgA antibodies were evaluated in all subjects. In the case of positivity to serology, diagnosis was confirmed by duodenal biopsy. One of 80 (1.25%) ICU patients were positive to both anti-transglutaminase and anti-endomysium antibodies. Duodenal biopsy showed partial villous atrophy. One control of 264 (0.38%) had CD. No statistical difference was found in the prevalence of CD between the two groups. ICU patients do not seem to bear a greater risk for CD compared to the general population.

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    • "In 1987, Hautekeete et al. first described the association between CD and CU [71], although this is a matter still under debate [73]. Indeed, the relationship between the two diseases is not clear [74], but it can be speculated that autoimmunity induced by gliadin or by other unknown antigens may link CU and CD. "
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    ABSTRACT: Celiac disease (CD) is an autoimmune gluten-dependent enteropathy characterized by atrophy of intestinal villi that improves after gluten-free diet (GFD). CD is often associated with extra-intestinal manifestations; among them, several skin diseases are described in CD patients. The present review reports all CD-associated skin manifestations described in the literature and tries to analyze the possible mechanisms involved in this association. The opportunity to evaluate the possible presence of CD in patients affected by skin disorders is discussed.
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