Male genital tract infection: The point of view of the bacteriologist

ArticleinGynécologie Obstétrique & Fertilité 33(9):691-7 · October 2005with12 Reads
DOI: 10.1016/j.gyobfe.2005.07.008 · Source: PubMed
Male genital tract infection and inflammation have been associated to 8 to 35% of male infertility cases in various studies. Their investigation is part of a multi-disciplinary process including new techniques as DNA integrity study. Bacterial seminal infection can cause transient or chronic persistent inflammation, and the microbiological investigations, as well as leukospermia, secretory chlamydial IgA and inflammatory cytokines help to approach the responsibility of inflammation in infertility or pathological condition, leading to antibiotic and anti-inflammatory treatment. In Assisted Reproductive Techniques (ART), bacteriospermia must be eradicated for a safe semen preparation to inseminate or to fertilize oocytes. Leukocytes cannot be completely eliminated by sperm preparation and the presence of antibiotics and antioxydants in the culture media is questionned.
    • "Various infectious agents i.e. bacteria, fungi, viruses and parasites can cause reproductive disturbance in both sexes. About 8-35% of the male infertility cases have been associated with infections and inflammation of the male genitourinary tract [1, 7]. Different parts of the male reproductive tract, such as the testis, epididymis and accessory sex glands can be easily affected by these infectious agents. "
    [Show abstract] [Hide abstract] ABSTRACT: Male infertility is a worldwide problem, as in about one in five infertile couples; the sole reason is the male partner. Amongst the various etiological factors responsible for male infertility, acute and chronic genital tract infections constitute a significant part. Different microorganisms have been linked with male infertility; with varying levels of association. These microorganisms have been known to employ different mechanisms ranging from direct effect on spermatozoa such as reduced motility, agglutination, loss of acrosomal reaction, to an indirect effect by inducing leukocytospermia that can adversely affect spermatozoa. They may also lead to deterioration of spermatogenesis, loss of sperm function and/or blockage of the seminal tract. This review summarizes the various patho mechanisms being employed by different microorganisms for causing decreased reproductive potential.
    Full-text · Article · Feb 2016 · Animal reproduction science
    • "Syphilis infection of the reproductive tract[8]can cause inflammatory disease and infertility[9]. Reproductive tract infection and inflammation cause 8% and 35% of all cases of male infertility, respectively [10]. In women, it can result in fallopian tube obstruction[11,12] and endometritis. "
    [Show abstract] [Hide abstract] ABSTRACT: To compare the clinical outcomes of infertile patients with and without syphilis after in vitro fertilization and embryo transfer (IVF-ET), in this case-control study, 320 infertile couples were enrolled and divided into syphilis (n = 160) and control groups (n = 160). The primary IVF outcomes were the clinical pregnancy rate and the birth of a healthy baby. All syphilis patients received the standard anti-syphilis treatment before undergoing IVF/ICSI. Our results showed that the endometrial thickness of the syphilis group was greater than that of the control group following hCG injection (16.9±5.4 vs. 13.0±4.7 mm, P<0.001). The numbers of normally fertilized eggs and normally cleaved fertilized eggs and the implantation rate were 6.8±4.8, 6.3±4.7 and 24.2%, respectively, for the syphilis group and 8.3±4.6, 8.1±4.6 and 34.4%, respectively, for the control group, and these values were significantly different between the groups. The clinical pregnancy rate was lower in the syphilis group compared with that in the control group (43.8% vs. 55.6%, P = 0.03). Lower offspring birth weight was observed in the infected male group compared with those in the infected female (2.7±0.4 vs. 3.0±0.4 kg, P = 0.01) and infected couple groups (2.7±0.4 vs. 3.1±0.5 kg, P = 0.007). Therefore, syphilis infection reduces the clinical pregnancy rate after IVF/ICSI.
    Full-text · Article · Jul 2015
    • "In birds, E. coli could be transmitted to the progeny through copulation. Microorganisms present in the seminal fluid or attached to spermatozoa are transmitted to females (Barnes and Gross, 1997; Jacobs et al., 1978; Poiani, 2010) causing reproductive tract infections (Askienazy-Elbhar, 2005) and embryonic mortality (Reid et al., 1961). Despite the numerous publications concerning sperm infection, to date, there are no data on the potential impact that could be related to resistant E. coli contamination. "
    [Show abstract] [Hide abstract] ABSTRACT: Extended spectrum β-lactamases (ESBL)-producing Escherichia coli have emerged worldwide in animal husbandry and they were reported from different ecosystems. The purpose of this study was firstly, to investigate the presence of ESBL-producing E. coli in the gastrointestinal (GIT) and reproductive (RT) tracts of broiler breeding roosters, and secondly to study the impact of an ESBL-producing E. coli on artificially infected semen. A total of seventeen ESBL-producing E. coli strains were isolated from the gastrointestinal and reproductive tracts of nine broiler breeding roosters. All isolates were identified to the species level by API 20E system and MALDI-TOF, serotyped, and genetically characterized for ESBL production. Semen was artificially infected with E. coli ATCC25922 or with an ESBL-producing E. coli strain recovered from the reproductive tract. A computer aided semen analyzer (CASA) was used to compare different spermatozoa motility parameters in each sample. All ESBL-producing E. coli isolates could not be typed with the currently used sera and they were harboring a blaCTX-M gene alone or in combination with a blaTEM gene. The semen quality was notably less affected in samples infected with ESBL-producing E. coli strain compared to the control and sample infected with E. coli ATCC25922. The present study revealed that ESBL-producing E. coli can be isolated from both reproductive and digestive tracts of broiler breeding roosters. Contamination of the reproductive tract with ESBL-producing E. coli could lead to contamination of semen and could be an important factor in the dissemination of ESBL-producing E. coli in poultry. Copyright © 2015 Elsevier B.V. All rights reserved.
    Full-text · Article · Jun 2015
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