Pt-Catalyzed Pentannulations from In Situ Generated Metallo−Carbenoids Utilizing Propargylic Esters

Department of Chemistry, University of California, Berkeley, Berkeley, California, United States
Journal of the American Chemical Society (Impact Factor: 12.11). 10/2005; 127(36):12468-9. DOI: 10.1021/ja053192c
Source: PubMed


A highly selective and efficient Pt-catalyzed pentannulation reaction beginning from propargylic esters is described. The key to this reaction is the use of a PtCl2(PPh3)2/PhIO catalyst combination that allows the in situ generation of Pt-carbenoid intermediates, which lead to good yields (61-84%) of the desired pentannulated compounds.

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