Diffusion Tensor Imaging in Late Posttraumatic Epilepsy

Department of Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Epilepsia (Impact Factor: 4.57). 10/2005; 46(9):1465-71. DOI: 10.1111/j.1528-1167.2005.01205.x
Source: PubMed


The main objective of this study was to use diffusion tensor imaging (DTI) to search and quantify the extent of abnormality beyond the obvious lesions seen on the T2 and fluid-attenuation inversion recovery (FLAIR) magnetic resonance images in patients with chronic traumatic brain injury (TBI) with and without epilepsy.
DTI was performed on 23 chronic TBI patients (with late posttraumatic epilepsy, n=14; without epilepsy, n=9) and 11 age-matched controls. The ratios of fractional anisotropy (FA) and mean diffusivity (MD) between the regions of interest beyond the T2/FLAIR-visualized abnormality and the corresponding contralateral normal-appearing region were calculated. FA and MD ratios were compared for relative changes in these parameters among the TBI subjects with and without epilepsy and controls. Tissue volumes exhibiting abnormalities on DTI also were measured in these patients.
The mean regional FA ratio was significantly lower, whereas the mean regional MD value was higher in patients with TBI compared with controls. The mean regional FA ratio was significantly lower in TBI patients with epilepsy (0.57+/-0.059) than in those without epilepsy (0.68+/-0.039). Although the regional MD ratio was higher in TBI patients with epilepsy (1.15+/-0.140) relative to those without epilepsy (1.09+/-0.141), the difference did not reach statistical significance. The tissue volume with low FA value also was found to be higher in TBI patients with epilepsy than without.
Severity of injury as predicted by the DTI-derived increased volume of microstructure damage is associated with delayed posttraumatic epilepsy in TBI patients. These findings could be valuable in predicting epileptogenesis in patients with chronic TBI.

Download full-text


Available from: Atul Agarwal, Nov 21, 2014
  • Source
    • "Diffusion tensor imaging (DTI) is currently widely used to evaluate normal and abnormal brain development [21] [22] [23] [24] [25] [26] [27] [28] [29]. This technique improves detection of microstructural damage in a wide range of neurologic disorders following interventions [24] [25] [26] [27] [28] [29]. A number of studies have evaluated the relationship between clinical grade and white matter (WM) injury using DTI in children with cerebral palsy [29] [30] [31] [32]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: The present study was to compare the effects of combined therapy [botulinum (BTX) plus physiotherapy] with physiotherapy alone using diffusion tensor imaging (DTI) derived fractional anisotropy (FA) values of motor and sensory fiber bundles and clinical grade of the disability to see the value of BTX in term children with spastic diplegic cerebral palsy (CP). Clinically diagnosed 36 children participated in the study. All these children were born at term, and had no history of seizures. The study was randomly categorized into two groups: group I (n=18) - physiotherapy alone and group II (n=18) - physiotherapy plus BTX injection. Quantitative diffusion tensor tractography on all these children was performed on motor and sensory fiber bundles on baseline as well as after 6months of therapy. Motor function and clinical grades were also measured by gross motor function measures (GMFM) scale on both occasions. We observed significant change in FA value in motor and sensory fiber bundle as well as in GMFM scores at 6months compared to baseline study in both the groups. However, delta change and relative delta change in FA values of sensory and motor fiber bundle as well as GMFM score between group I and group II was statistically insignificant. We conclude that addition of BTX to physiotherapy regimen does not influence the outcome at 6months with similar insult in children with term diplegic spastic CP. This information may influence management of diplegic CP especially in developing countries, where BTX is beyond the reach of these children.
    Full-text · Article · Nov 2012 · Brain & development
  • Source
    • "Diffusion tensor imaging (DTI) offers the possibility of estimating quantities related to the brain's microstructure (Basser et al., 1994; Le Bihan et al., 1986; Pierpaoli and Basser, 1996; Turner et al., 1990). DTI indices, such as the mean diffusivity (MD) or the fractional anisotropy (FA), are often used in research studies to correlate function with structure (Powell et al., 2006; Vernooij et al., 2007) as well as in clinical DTI studies to identify diseased areas in white matter (WM) microstructure (Deppe et al., 2008; Gupta et al., 2005; Horsfield and Jones, 2002; Kleffner et al., 2008; Meinzer et al., 2010) or even in grey matter (Keller et al., in press). DTI is susceptible to imaging artefacts, which can vary significantly between magnetic resonance imaging (MRI) scanners. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Indices derived from diffusion tensor imaging (DTI) data, including the mean diffusivity (MD) and fractional anisotropy (FA), are often used to better understand the microstructure of the brain. DTI, however, is susceptible to imaging artefacts, which can bias these indices. The most important sources of artefacts in DTI include eddy currents, nonuniformity and mis-calibration of gradients. We modelled these and other artefacts using a local perturbation field (LPF) approach. LPFs during the diffusion-weighting period describe the local mismatches between the effective and the expected diffusion gradients resulting in a spatially varying error in the diffusion weighting B matrix and diffusion tensor estimation. We introduced a model that makes use of phantom measurements to provide a robust estimation of the LPF in DTI without requiring any scanner-hardware-specific information or special MRI sequences. We derived an approximation of the perturbed diffusion tensor in the isotropic-diffusion limit that can be used to identify regions in any DTI index map that are affected by LPFs. Using these models, we simulated and measured LPFs and characterised their effect on human DTI for three different clinical scanners. The small FA values found in grey matter were biased towards greater anisotropy leading to lower grey-to-white matter contrast (up to 10%). Differences in head position due to e.g. repositioning produced errors of up to 10% in the MD, reducing comparability in multi-centre or longitudinal studies. We demonstrate the importance of the proposed correction by showing improved consistency across scanners, different head positions and an increased FA contrast between grey and white matter.
    Full-text · Article · Dec 2011 · NeuroImage
  • Source
    • "Fractional anisotropy (FA) is a measure of the directional diffusion of water, values range from 0 (completely anisotropic or randomly directed) to 1 (completely isotropic or uni-directional). FA scores increase in healthy children with better reading and spelling skills (Deutsch et al. 2005) and cognitive performance (Schmithorst et al. 2005) and decrease in adults with multiple sclerosis (Horsfield et al. 1998), traumatic brain injury (Gupta et al. 2005) and normal and abnormal ageing (Moseley, 2002). This makes it a useful tool to detect and quantify dynamic changes in white matter microstructure during neurodevelopment and degeneration of the brain. "
    [Show abstract] [Hide abstract]
    ABSTRACT: We investigated cerebral structural connectivity and its relationship to symptoms in never-medicated individuals with first-onset schizophrenia using diffusion tensor imaging (DTI). Method: We recruited subjects with first episode DSM-IV schizophrenia who had never been exposed to antipsychotic medication (n=34) and age-matched healthy volunteers (n=32). All subjects received DTI and structural magnetic resonance imaging scans. Patients' symptoms were assessed on the Positive and Negative Syndrome Scale. Voxel-based analysis was performed to investigate brain regions where fractional anisotropy (FA) values significantly correlated with symptom scores. In patients with first-episode schizophrenia, positive symptoms correlated positively with FA scores in white matter associated with the right frontal lobe, left anterior cingulate gyrus, left superior temporal gyrus, right middle temporal gyrus, right middle cingulate gyrus, and left cuneus. Importantly, FA in each of these regions was lower in patients than controls, but patients with more positive symptoms had FA values closer to controls. We found no significant correlations between FA and negative symptoms. The newly-diagnosed, neuroleptic-naive patients had lower FA scores in the brain compared with controls. There was positive correlation between FA scores and positive symptoms scores in frontotemporal tracts, including left fronto-occipital fasciculus and left inferior longitudinal fasciculus. This implies that white matter dysintegrity is already present in the pre-treatment phase and that FA is likely to decrease after clinical treatment or symptom remission.
    Full-text · Article · Aug 2011 · Psychological Medicine
Show more